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32161

Gamithromycin

VETRANAL®, analytical standard

Synonym(s):

(2R,3S,4R,5S,8RR,10R,11R,12S,13S,14R)-13-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylohexopyranosyl]oxy]-1-oxa-7-azacyclopentadecan-15-one

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About This Item

Empirical Formula (Hill Notation):
C40H76N2O12
CAS Number:
Molecular Weight:
777.04
MDL number:
UNSPSC Code:
41116107
NACRES:
NA.24
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grade

analytical standard

Quality Level

product line

VETRANAL®

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
veterinary

format

neat

storage temp.

2-8°C

SMILES string

N1([C@@H](C[C@]([C@@H](C([C@@H]([C@H](C(=O)O[C@@H]([C@]([C@@H]([C@H](C1)C)O)(O)C)CC)C)O[C@@H]3O[C@H]([C@@H]([C@@](C3)(OC)C)O)C)C)O[C@@H]2O[C@@H](C[C@@H]([C@H]2O)N(C)C)C)(O)C)C)CCC

InChI

1S/C40H76N2O12/c1-15-17-42-21-22(3)33(44)40(11,48)29(16-2)52-36(46)26(7)32(53-30-20-39(10,49-14)34(45)27(8)51-30)25(6)35(38(9,47)19-23(42)4)54-37-31(43)28(41(12)13)18-24(5)50-37/h22-35,37,43-45,47-48H,15-21H2,1-14H3/t22-,23+,24+,25?,26+,27-,28-,29+,30-,31+,32-,33+,34-,35+,37-,38+,39+,40+/m0/s1

InChI key

VWAMTBXLZPEDQO-FWEXOAGLSA-N

General description

Gamithromycin is a drug, which is administered to cattle for the treatment of bovine respiratory disease caused by Pasteurella multocida, Histophilus somni and Mannheimia haemolytica. It is also effective in treating certain infections caused by Mycoplasma.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Gamithromycin may be used as a reference standard in the determination of gamithromycin in samples of plasma, lung tissue and pulmonary epithelial lining fluid using liquid chromatography coupled with tandem mass spectrometry (LC-MS-MS).

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

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This Item
PHR168632671A6848
application(s)

forensics and toxicology
veterinary

application(s)

pharmaceutical (small molecule)

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

grade

analytical standard

grade

certified reference material, pharmaceutical secondary standard

grade

analytical standard

grade

analytical standard

format

neat

format

neat

format

neat

format

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

storage temp.

-

Quality Level

100

Quality Level

300

Quality Level

100

Quality Level

100


pictograms

Health hazardExclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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Saunders Handbook of Veterinary Drugs: Small and Large Animal (2015)
Yu-Feng Zhou et al.
BMC veterinary research, 16(1), 81-81 (2020-03-07)
Gamithromycin is a macrolide approved for the treatment of bovine and swine respiratory diseases. Our study aims to establish the clinical breakpoint and optimum dose regimen for gamithromycin against Haemophilus parasuis in piglets. Gamithromycin was well absorbed and fully bioavailable
Michael Kellermann et al.
Research in veterinary science, 97(2), 199-203 (2014-09-23)
This study assessed the plasma kinetics and skin/plasma concentration ratio of the azalide antibiotic gamithromycin (ZACTRAN(®), Merial) in sheep after a single subcutaneous administration at 6 mg/kg bodyweight. Gamithromycin concentrations in plasma samples collected at various intervals up to 21



Global Trade Item Number

SKUGTIN
32161-25MG04061826702451

Questions

  1. I would like to know about the solubility of gamithromycin. in which solvent is it recommended to be solubilized and at what maximum concentration?

    1 answer
    1. The solubility of this product is not determined. However, literature indicates that gamithromycin is typically soluble in DMSO. The exact concentration at which it can be solubilized is not determined.

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