We have found the information on transferrin in a reference book:The Plasma Proteins, F.W. Putnam, ed, volume 2, chapter 4, Table II.According to the table, Transferrin is 6 percent carbohydrate, citing G.A. Jamieson, J. Biol. Chem. 240(7), 2914-2920 (1965).The table also gives information on the percentage of each type of monosaccharide that is present.
T2252
apo-Transferrin human
≥95% protein basis (biuret)
Synonym(s):
Human transferrin, Siderophilin
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About This Item
CAS Number:
UNSPSC Code:
12352202
EC Number:
234-318-8
NACRES:
NA.61
MDL number:
eCl@ss:
34058011
Form:
powder
Assay:
≥95% protein basis (biuret), ≥98% (agarose gel electrophoresis)
Biological source:
human
Mol wt:
76-81 kDa
Pricing and availability is not currently available.
General description
Transferrin is a bilobed glycoprotein containing an N-terminal lobe and a C-terminal lobe. Each of these domains is divided into two sub-domains and within the inter subdomain cleft is the metal-binding site. A single transferrin molecule can bind to two ferric ions. Apo-transferrin is an iron-free form.[1]
Application
Apo-transferrin has been shown to strongly inhibit bacterial adhesion to biomaterials including polystyrene, polymethylmethacrylate, and silicone. Inhibition was seen at twenty micrograms/ml in culture medium. [2]
Biochem/physiol Actions
Transferrin transports iron through receptor-mediated endocytosis. The iron transport mechanism occurs in the endothelial cells of the blood-brain barrier. Transferrin maintains iron homeostasis[1] and is an iron-associated marker. Reduced levels of transferrin are observed in severe COVID-19 conditions.[6] It may bind to other molecules apart from iron, hence it can be used in targeted drug delivery.[1]
Other Notes
Non-heme iron-transport protein.
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
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This Item | |||
|---|---|---|---|
| biological source human | biological source - | biological source - | biological source human plasma |
| technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable |
| assay ≥95% protein basis (biuret), ≥98% (agarose gel electrophoresis) | assay ≥98% (agarose gel electrophoresis) | assay ≥98% | assay ≥98% (agarose gel electrophoresis) |
| mol wt 76-81 kDa | mol wt 76-81 kDa | mol wt 76-81 kDa | mol wt 76-81 kDa |
| form powder | form powder | form powder | form powder |
| Gene Information human ... TF(7018) | Gene Information human ... TF(7018) | Gene Information human ... TF(7018) | Gene Information human ... TF(7018) |
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Storage Class
11 - Combustible Solids
wgk
WGK 3
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Related Content
Instructions
Camila Campos-Escamilla et al.
International journal of molecular sciences, 22(24) (2021-12-25)
Human serum transferrin (Tf) is a bilobed glycoprotein whose function is to transport iron through receptor-mediated endocytosis. The mechanism for iron release is pH-dependent and involves conformational changes in the protein, thus making it an attractive system for possible biomedical
Reza Ardehali et al.
Artificial organs, 26(6), 512-520 (2002-06-20)
Apo-transferrin (apo-Tf), the iron deficient form of Tf, has been identified previously as a potent inhibitor of Staphylococcus epidermidis adhesion to polyurethane surfaces. In this study, the ability of apo-Tf to suppress the adhesion of two other strains of bacteria
Jacob M Smigiel et al.
Molecular cancer research : MCR, 15(4), 478-488 (2017-01-06)
Pancreatic ductal adenocarcinoma (PDAC) is referred to as a silent killer due to the lack of clear symptoms, a lack of early detection methods, and a high frequency of metastasis at diagnosis. In addition, pancreatic cancer is remarkably resistant to
Global Trade Item Number
| SKU | GTIN |
|---|---|
| T2252-500MG | 04061837341908 |
| T2252-100MG | 04061837341885 |
| T2252-5G | 04061837341922 |
| T2252-1G | 04061837341892 |
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What is the carbohydrate content of human transferrin?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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