This compound is not listed as being light sensitive. However, the material is air sensitive and packaged under argon. The product is soluble in water and DMSO at 40 mg/mL. The stability of this compound in solution has not been investigated. External sources indicate that aqueous solution may degrade rapidly. Stock solutions in DMSO may be stable for up to 6 months at -20°C and up to 1 years at -80°C when stored in working aliquots. Avoid repeated freeze/thaw cycles.
SML2304
Clozapine N-oxide hydrochloride
≥98% (HPLC), powder, muscarinic DREADD activator
Synonym(s):
Clozapine N-oxide hydrochloride, 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e](1,4)diazepine N-oxide, hydrochloride salt
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About This Item
Empirical Formula (Hill Notation):
C18H19ClN4O · xHCl
CAS Number:
Molecular Weight:
342.82 (free base basis)
UNSPSC Code:
12352119
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
Pricing and availability is not currently available.
Product Name
Clozapine N-oxide hydrochloride, ≥98% (HPLC), Water soluble Clozapine N-oxide
biological source
synthetic
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
solubility
DMSO: 40 mg/mL, water: 40 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
ClC1=CC2=C(NC(C=CC=C3)=C3C(N4CC[N+]([O-])(C)CC4)=N2)C=C1.[xHCl]
InChI
1S/C18H19ClN4O/c1-23(24)10-8-22(9-11-23)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
InChI key
OGUCZBIQSYYWEF-UHFFFAOYSA-N
General description
Clozapine N-oxide hydrochloride is a water soluble form of Clozapine N-oxide (CNO) (Sigma cat# C0832). CNO is a pharmacologically inert metabolite of the atypical anti-psychotic drug clozapine. CNO is a ligand for the engineered Gq protein coupled receptors (GPCRs) in the chemogenetic Designer Receptors Exclusively Activated by Designer Drug (DREADD). The typical use of DREADD is testing, enhancing neuronal firing and activating Gq signaling in neuronal and non-neuronal cells.
The selective targeting of DREADD systems to cell population can be achieved by using a cell type-specific promoter to drive DREADD expression, and the expression of this promoter can be further controlled using a recombinase-based system. DREADDs possess a low affinity for endogenous ligands and little constitutive activity, but may be activated by synthetic compounds such as CNO.
DREADD systems are activated by low nM concentrations of CNO and mobilize intracellular calcium. CNO appears to be pharmacologically and behaviorally inert in mice and rats when administered at the recommended doses (generally 0.1–3 mg/kg). CNO is commonly administrated via injection but also can be mixed into food chow or drinking water.
The selective targeting of DREADD systems to cell population can be achieved by using a cell type-specific promoter to drive DREADD expression, and the expression of this promoter can be further controlled using a recombinase-based system. DREADDs possess a low affinity for endogenous ligands and little constitutive activity, but may be activated by synthetic compounds such as CNO.
DREADD systems are activated by low nM concentrations of CNO and mobilize intracellular calcium. CNO appears to be pharmacologically and behaviorally inert in mice and rats when administered at the recommended doses (generally 0.1–3 mg/kg). CNO is commonly administrated via injection but also can be mixed into food chow or drinking water.
Other Notes
This is not a pharmaceutical grade product.
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This Item | |||
|---|---|---|---|
| form powder | form solid | form powder | form powder |
| assay ≥98% (HPLC) | assay - | assay - | assay ≥98% (HPLC) |
| storage temp. 2-8°C | storage temp. - | storage temp. - | storage temp. - |
| solubility DMSO: 40 mg/mL, water: 40 mg/mL | solubility - | solubility ethanol: 1 mg/mL, 0.1 M HCl: 30 mg/mL, DMSO: 4.8 mg/mL | solubility H2O: 25 mg/mL, 0.1 M HCl: soluble |
| storage condition desiccated | storage condition - | storage condition - | storage condition - |
| biological source synthetic | biological source - | biological source - | biological source - |
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - STOT SE 3
target_organs
Central nervous system
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML2304-5MG | 04061838662064 |
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Is this light-sensitive? Could you provide information about its stability after dissolution at room temperature?
1 answer-
Helpful?
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Is Clozapine N-Oxide pharmaceutical grade?
1 answer-
This is not a pharmaceutical grade product. Unfortunately, a pharmaceutical grade is not offered.
Helpful?
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