The product is not assigned an expiration date. In the original sealed container it is quite stable. A warranty of 1 year from the date of shipment applies. It should be stored at −20°C in the powdered format. Following reconstitution in DMSO at 0.5 mg/mL, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
SML1094
CHIR 98014
≥98% (HPLC), powder, GSK-3 inhibitor
Synonym(s):
N-6-[2-[[4-(2,4-Dichlorophenyl)-5-(1H-imidazol-1-yl)-2-pyrimidinyl]amino]ethyl]-3-nitro-2,6-pyridinediamine, CHIR-98014
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About This Item
Empirical Formula (Hill Notation):
C20H17Cl2N9O2
CAS Number:
Molecular Weight:
486.31
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Pricing and availability is not currently available.
Product Name
CHIR 98014, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to brown
solubility
DMSO: 0.5 mg/mL, clear (warmed)
storage temp.
−20°C
SMILES string
NC1=C(C=CC(NCCNC2=NC(C3=C(Cl)C=C(Cl)C=C3)=C(N4C=CN=C4)C=N2)=N1)[N+]([O-])=O
InChI
1S/C20H17Cl2N9O2/c21-12-1-2-13(14(22)9-12)18-16(30-8-7-24-11-30)10-27-20(29-18)26-6-5-25-17-4-3-15(31(32)33)19(23)28-17/h1-4,7-11H,5-6H2,(H3,23,25,28)(H,26,27,29)
InChI key
MDZCSIDIPDZWKL-UHFFFAOYSA-N
Application
CHIR 98014 has been used for the generation of small molecules neural progenitor cells and differentiation towards motor neurons.[1] It has also been used as a Wnt/β-catenin pharmacological agonist in the cell-conditioned medium to perform chromatin immunoprecipitation (ChIP) studies in HT22 neurons.[2]
Biochem/physiol Actions
CHIR 98014 is a glycogen synthase kinase-3 (GSK-3) inhibitor with IC50 values of 0.65 nM and 0.58 nM for GSK3α and GSK3β, respectively. CHIR98014 is 500-fold to >10,000-fold selectivity for GSK-3 versus 20 other protein kinases tested, including closest homologs Cdc2 and ERK2.
CHIR 98014 is a glycogen synthase kinase-3 (GSK-3) inhibitor.
Preparation Note
Reconstitute in DMSO at 0.5 mg/mL. Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
The product in the original sealed container is quite stable. It should be stored at −20°C in the powdered format.
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This Item | |||
|---|---|---|---|
| form powder | form powder | form powder | form powder |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 200 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C | storage temp. −20°C |
| solubility DMSO: 0.5 mg/mL, clear (warmed) | solubility DMSO: 5 mg/mL, clear (warmed) | solubility DMSO: 20 mg/mL, clear | solubility DMSO: 20 mg/mL, clear |
| color white to brown | color white to beige | color white to beige | color white to light brown |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Matías A Medina et al.
Translational psychiatry, 8(1), 45-45 (2018-03-06)
Synaptic abnormalities have been described in individuals with autism spectrum disorders (ASD). The cell-adhesion molecule Neuroligin-3 (Nlgn3) has an essential role in the function and maturation of synapses and NLGN3 ASD-associated mutations disrupt hippocampal and cortical function. Here we show
Selective activation of FZD7 promotes mesendodermal differentiation of human pluripotent stem cells.
Diana Gumber et al.
eLife, 9 (2020-12-18)
WNT proteins are secreted symmetry breaking signals that interact with cell surface receptors of the FZD family to regulate a multitude of developmental processes. Studying selectivity between WNTs and FZDs has been hampered by the paucity of purified WNT proteins
Paola Rusmini et al.
Autophagy, 15(4), 631-651 (2018-10-20)
Macroautophagy/autophagy, a defense mechanism against aberrant stresses, in neurons counteracts aggregate-prone misfolded protein toxicity. Autophagy induction might be beneficial in neurodegenerative diseases (NDs). The natural compound trehalose promotes autophagy via TFEB (transcription factor EB), ameliorating disease phenotype in multiple ND
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML1094-5MG | 04061832434292 |
| SML1094-25MG | 04061832434285 |
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What are the storage conditions and expiry for this product in its original form and once reconstituted? Material: CHIR-98014 SML1094-25MG
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