Key Documents

PR-619

Name: PR-619
Brand: SIGMA

≥95% (HPLC), deubiquitylating enzymes (DBUs) inhibitor, powder

Synonym(s):

2,6-Diamino-3,5-dithiocyanopyridine, Thiocyanic acid C,C′-(2,6-diamino-3,5-pyridinediyl) ester; 2,6-Diaminopyridine-3,5-bis(thiocyanate)

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About This Item

Empirical Formula (Hill Notation):

C₇H₅N₅S₂

CAS Number:

2645-32-1

Molecular Weight:

223.28

UNSPSC Code:

12352200

PubChem Substance ID:

329825425

NACRES:

NA.77

MDL number:

MFCD00830384

Assay:

≥95% (HPLC)

Form:

powder

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Properties

Product Name

PR-619, ≥95% (HPLC)

Quality Segment

100

assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL (clear solution)

storage temp.

−20°C

SMILES string

Nc1nc(N)c(SC#N)cc1SC#N

InChI

1S/C7H5N5S2/c8-2-13-4-1-5(14-3-9)7(11)12-6(4)10/h1H,(H4,10,11,12)

InChI key

ZXOBLNBVNROVLC-UHFFFAOYSA-N

Description

Application

PR-619 has been used:

as a component of lysis buffer and also as a deubiquitinase inhibitor to treat proteins derived from SILAC-labeled Jurkat cells
as a pan-deubiquitinase inhibitor to study its effect on adenoassociated virus (AAV) transduction
in radioimmunoprecipitation assay buffer (RIPA) buffer used for ubiquitination assays

Biochem/physiol Actions

PR-619 cell permeable, broad spectrum deubiquitylating enzymes (DBUs) inhibitor; general deubiquitylase (DUB) inhibitor.

PR-619 is a cell permeable broad spectrum deubiquitylating enzymes (DBUs) inhibitor. PR-619 induces the accumulation of polyubiquitylated proteins in cells without directly affecting proteasome activity.

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This Item	SML1005	SML1043	662141
Sigma-Aldrich SML0430 PR-619	Sigma-Aldrich SML1005 NSC 617145	Sigma-Aldrich SML1043 KC7F2	Sigma-Aldrich 662141 DUB Inhibitor V, PR-619
form powder	form powder	form powder	form solid
assay ≥95% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥99% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. −20°C	storage temp. 2-8°C	storage temp. −20°C	storage temp. 2-8°C
solubility DMSO: 5 mg/mL (clear solution)	solubility DMSO: 3 mg/mL, clear (warmed)	solubility DMSO: 20 mg/mL, clear	solubility DMSO: 50 mg/mL
color white to beige	color white to light brown	color white to beige	color light beige to yellow

Storage Class

11 - Combustible Solids

wgk

WGK 3

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