P4154
Polyinosinic acid potassium salt
Homopolymer
Synonym(s):
Poly(I) potassium salt
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About This Item
Assay:
≥98% (TLC)
Biological source:
synthetic (organic)
Form:
lyophilized powder
Solubility:
water: 4.80-5.20 mg/mL, clear to hazy, colorless to faintly yellow
Storage temp.:
−20°C
Pricing and availability is not currently available.
biological source
synthetic (organic)
Quality Segment
assay
≥98% (TLC)
form
lyophilized powder
solubility
water: 4.80-5.20 mg/mL, clear to hazy, colorless to faintly yellow
storage temp.
−20°C
Application
Polyinosinic acid (Poly(I)) is a homopolymer of inosine that may be used with polycytidylic acid (poly(C)) to form the double-stranded homopolymer (Poly(I) • Poly(C)). TLR3 recognizes double-stranded RNA and is a major effector of the immune response against viral pathogens. (Poly(I) • Poly(C)) is a used as a model RNA to study cell signaling at the level of TLR3. Poly(IC) is a TRIF-dependent toll-like receptor-3 (TLR3) ligand.
Preparation Note
Prepared from IDP using polynucleotide phosphorylase.
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This Item | |||
|---|---|---|---|
| biological source synthetic (organic) | biological source - | biological source - | biological source - |
| Quality Level 200 | Quality Level 300 | Quality Level 200 | Quality Level 200 |
| form lyophilized powder | form lyophilized powder | form lyophilized powder | form - |
| assay ≥98% (TLC) | assay (Free nucleotides NMT 1% (TLC)) | assay ≥98% (TLC) | assay (Free nucleotides NMT 1% (TLC)) |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| solubility water: 4.80-5.20 mg/mL, clear to hazy, colorless to faintly yellow | solubility - | solubility water: 19.60-20.40 mg/mL, clear to slightly hazy, colorless | solubility - |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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