P4154

Polyinosinic acid potassium salt

Homopolymer

• Synonym(s): Poly(I) potassium salt
• CAS Number: 26936-41-4
• UNSPSC Code: 41106305
• NACRES: NA.51
• MDL number: MFCD00131982
• Assay: ≥98% (TLC)
• Biological source: synthetic (organic)
• Form: lyophilized powder
• Solubility: water: 4.80-5.20 mg/mL, clear to hazy, colorless to faintly yellow
• Storage temp.: −20°C

Properties

• biological source: synthetic (organic)
• Quality Segment: 200
• assay: ≥98% (TLC)
• form: lyophilized powder
• solubility: water: 4.80-5.20 mg/mL, clear to hazy, colorless to faintly yellow
• storage temp.: −20°C

Description

Application

Polyinosinic acid (Poly(I)) is a homopolymer of inosine that may be used with polycytidylic acid (poly(C)) to form the double-stranded homopolymer (Poly(I) • Poly(C)). TLR3 recognizes double-stranded RNA and is a major effector of the immune response against viral pathogens. (Poly(I) • Poly(C)) is a used as a model RNA to study cell signaling at the level of TLR3. Poly(IC) is a TRIF-dependent toll-like receptor-3 (TLR3) ligand.

Preparation Note

Prepared from IDP using polynucleotide phosphorylase.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)