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H-8 dihydrochloride

Name: H-8 dihydrochloride
Brand: SIGMA

>98% (HPLC)

Synonym(s):

N-[2-(Methylamino)ethyl]-5-isoquinolinesulfonamide hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₁₂H₁₅N₃O₂S · 2HCl

CAS Number:

113276-94-1

Molecular Weight:

338.25

NACRES:

NA.77

PubChem Substance ID:

24278039

UNSPSC Code:

12352200

MDL number:

MFCD00036962

Assay:

>98% (HPLC)

Form:

powder

Pricing and availability is not currently available.

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Properties

assay

>98% (HPLC)

form

powder

storage temp.

2-8°C

SMILES string

Cl[H].Cl[H].CNCCNS(=O)(=O)c1cccc2cnccc12

InChI

1S/C12H15N3O2S.2ClH/c1-13-7-8-15-18(16,17)12-4-2-3-10-9-14-6-5-11(10)12;;/h2-6,9,13,15H,7-8H2,1H3;2*1H

InChI key

RJJLZYZEVNCZIW-UHFFFAOYSA-N

Gene Information

human ... CALCRL(10203), PRKAR1A(5573), PRKAR1AP(5574), PRKAR1B(5575), PRKAR2A(5576), PRKAR2B(5577)
rat ... Calcrl(25029)

Description

Biochem/physiol Actions

cAMP and cGMP-dependent protein kinase inhibitor.

Features and Benefits

This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item	B1427	SML0128	SML0853
Sigma-Aldrich M9656 H-8 dihydrochloride	Sigma-Aldrich B1427 H-89 dihydrochloride hydrate	Sigma-Aldrich SML0128 M30 dihydrochloride	Sigma-Aldrich SML0853 SB 699551 dihydrochloride
form powder	form powder	form powder	form powder
assay >98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
Gene Information human ... CALCRL(10203), PRKAR1A(5573), PRKAR1AP(5574), PRKAR1B(5575), PRKAR2A(5576), PRKAR2B(5577) rat ... Calcrl(25029)	Gene Information human ... PRKAR1A(5573), PRKAR1AP(5574), PRKAR1B(5575), PRKAR2A(5576), PRKAR2B(5577)	Gene Information -	Gene Information -

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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TMEM16A-encoded anoctamin 1 inhibition contributes to chrysin-induced coronary relaxation.

Guijin Ma et al.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 131, 110766-110766 (2020-11-07)

Chrysin, a natural flavonoid available in honey, propolis and medicinal plants, has been shown to be vasorelaxant in some vascular beds. Proper intake of an alimental vasodilator as a food additive may be a promising strategy for prevention and treatment

In vitro activation and nuclear translocation of NF-kappa B catalyzed by cyclic AMP-dependent protein kinase and protein kinase C.

F Shirakawa et al.

Molecular and cellular biology, 9(6), 2424-2430 (1989-06-01)

We have examined whether a precursor form of NF-kappa B, a DNA-binding protein that plays a role in the transcriptional control of several genes, including kappa immunoglobulin light chain and interleukin-2 receptor alpha subunit, could be activated in vitro by

Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C.

H Hidaka et al.

Biochemistry, 23(21), 5036-5041 (1984-10-09)

Naphthalenesulfonamides such as N-(6-amino-hexyl)-5-chloro-1-naphthalenesulfonamide (W-7) are potent calmodulin (CaM) antagonists and act upon several protein kinases at higher concentration. When the naphthalene ring was replaced by isoquinoline, the derivatives were no longer CaM antagonists but retained the ability to inhibit

Global Trade Item Number

SKU	GTIN
M9656-5MG	04061832449012

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H-8 dihydrochloride

>98% (HPLC)

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About This Item

assay

form

storage temp.

SMILES string

InChI

InChI key

Gene Information

Biochem/physiol Actions

Features and Benefits

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Storage Class

wgk

flash_point_f

flash_point_c

ppe

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