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The solubility of this product in water is tested at 25 mg/ml. The peptide contains an oxidizable tryptophan, so the solvent should be bubbled with argon or nitrogen for deaeration. The solution should be stored frozen for up to six months in single-use aliquots to avoid freeze-thaw cycles.
L7134
Luteinizing hormone releasing hormone human acetate salt
≥98% (HPLC), powder
Synonym(s):
Gonadoliberin, Gonadotropin releasing hormone, LH-RH
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About This Item
Empirical Formula (Hill Notation):
C55H75N17O13
CAS Number:
Molecular Weight:
1182.29
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
Pricing and availability is not currently available.
Quality Segment
assay
≥98% (HPLC)
form
powder
mol wt
Mr 1182.33
UniProt accession no.
storage temp.
−20°C
SMILES string
CC(O)=O.CC(O)=O.CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc4c[nH]cn4)NC(=O)[C@@H]5CCC(=O)N5)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N6CCC[C@H]6C(=O)NCC(N)=O
InChI
1S/C55H75N17O13.2C2H4O2/c1-29(2)19-38(49(80)67-37(9-5-17-60-55(57)58)54(85)72-18-6-10-43(72)53(84)62-25-44(56)75)66-46(77)26-63-47(78)39(20-30-11-13-33(74)14-12-30)68-52(83)42(27-73)71-50(81)40(21-31-23-61-35-8-4-3-7-34(31)35)69-51(82)41(22-32-24-59-28-64-32)70-48(79)36-15-16-45(76)65-36;2*1-2(3)4/h3-4,7-8,11-14,23-24,28-29,36-43,61,73-74H,5-6,9-10,15-22,25-27H2,1-2H3,(H2,56,75)(H,59,64)(H,62,84)(H,63,78)(H,65,76)(H,66,77)(H,67,80)(H,68,83)(H,69,82)(H,70,79)(H,71,81)(H4,57,58,60);2*1H3,(H,3,4)/t36-,37-,38-,39-,40-,41-,42-,43-;;/m0../s1
InChI key
QOVPLTBEZAJSHY-VIRDRFNDSA-N
Gene Information
human ... GNRH1(2796)
Application
Luteinizing hormone releasing hormone human acetate salt has been used:
- for synchronization of the ovulations
- for pre-absorption of the anti-GnRH antibody in staining procedures
- to study pituitary sensitivity to GnRH in presence of endocrine disrupting compound
Biochem/physiol Actions
Hypothalamic peptide that stimulates release of gonadotrophins from anterior pituitary, thus regulating reproductive functions.
Stimulates release of gonadotrophins from anterior pituitary.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Other Notes
Lyophilized from 0.5% acetic acid
free peptide
pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2
1 of 1
This Item | |||
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥97% (HPLC) | assay ≥97% (HPLC) | assay ≥97% (HPLC) |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| form powder | form - | form powder | form powder |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| mol wt Mr 1182.33 | mol wt - | mol wt - | mol wt - |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. - |
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
target_organs
Endocrine system
signalword
Warning
hcodes
Hazard Classifications
Repr. 2 - STOT RE 2
Storage Class
11 - Combustible Solids
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| L7134-5MG | 04061835557592 |
| L7134-1MG | 04061826152973 |
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製品番号 L7134-5MG（GnRH/LHRH, acetate salt）について質問です。 ヒト多能性幹細胞由来視床下部‐下垂体オルガノイド培養で使用予定です。本製品の水溶液および細胞培養培地中（37°C）における化学的安定性について、以下をご教示ください。 (1) PBS/水中での再溶解後の使用可能時間 (2) 細胞培養培地中での安定性（DMEM/F12＋BSA、血清有無） (3) 推奨保存条件とアリコート化 (4) 凍結融解の許容性
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