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Lomefloxacin hydrochloride

Name: Lomefloxacin hydrochloride
Brand: SIGMA

Synonym(s):

1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₁₉F₂N₃O₃ · HCl

CAS Number:

98079-52-8

Molecular Weight:

387.81

NACRES:

NA.85

PubChem Substance ID:

24278514

UNSPSC Code:

51282927

MDL number:

MFCD00214312

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Properties

biological source

synthetic

Quality Level

200

color

white to off-white

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

DNA synthesis | interferes, enzyme | inhibits

storage temp.

−20°C

SMILES string

Cl.CCN1C=C(C(O)=O)C(=O)c2cc(F)c(N3CCNC(C)C3)c(F)c12

InChI

1S/C17H19F2N3O3.ClH/c1-3-21-8-11(17(24)25)16(23)10-6-12(18)15(13(19)14(10)21)22-5-4-20-9(2)7-22;/h6,8-9,20H,3-5,7H2,1-2H3,(H,24,25);1H

InChI key

KXEBLAPZMOQCKO-UHFFFAOYSA-N

Description

General description

Chemical structure: fluoroquinolone

Application

Lomefloxacin is a fluoroquinolone antibiotic that is commonly used to treat bacterial infections, including bronchitis and urinary tract infections. It is used as a pre-operative prophylactic to prevent urinary tract infection caused by S. pneumoniae, H. influenzae, S. aureus, P. aeruginosa, E. cloacae, P. mirabilis, C. civersus, S. asprphyticus, E. coli, and K. pneumoniae. It is used to induce genomic instability in mice[1] and modification of the kinetics of growth of Gram-negative bacteria[2].

Biochem/physiol Actions

Lomefloxacin is a bactericidal fluoroquinolone agent that is active against gram-negative and gram-positive organisms. Lomefloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase is thought to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV is thought to be the primary target in gram-positive organisms. The inhibition of the topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. Therefore, DNA replication and transcription is inhibited.

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This Item	P0106	17850	33434
Sigma-Aldrich L2906 Lomefloxacin hydrochloride	Sigma-Aldrich P0106 Pefloxacin mesylate dihydrate	Sigma-Aldrich 17850 Ciprofloxacin	Supelco 33434 Ciprofloxacin
antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria	antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria	antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria	antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria
mode of action enzyme \| inhibits, DNA synthesis \| interferes	mode of action DNA synthesis \| interferes, enzyme \| inhibits	mode of action DNA synthesis \| interferes, enzyme \| inhibits	mode of action DNA synthesis \| interferes, enzyme \| inhibits
Quality Level 200	Quality Level 100	Quality Level 200	Quality Level 100
storage temp. −20°C	storage temp. 2-8°C	storage temp. -	storage temp. -
biological source synthetic	biological source -	biological source -	biological source -
color white to off-white	color -	color -	color -

pictograms

GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number

0000519640

0000488018

0000438505

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Comparison of binding interactions of lomefloxacin to serum albumin and serum transferrin by resonance light scattering and fluorescence quenching methods.

H Vahedian-Movahed et al.

Journal of biomolecular structure & dynamics, 28(4), 483-502 (2010-12-15)

The interaction between lomefloxacin (LMF) and two drug carrier proteins, human serum albumin (HSA) and serum transferrin (TF), were studied and compared by fluorescence quenching, resonance light scattering (RLS), and circular dichroism (CD) spectroscopic along with molecular modeling. Fluorescence data

Abatement by naringin of lomefloxacin-induced genomic instability in mice.

Sabry M Attia

Mutagenesis, 23(6), 515-521 (2008-08-30)

Lomefloxacin is a difluorinated quinolone antibacterial drug. It is widely used against infectious diseases including meningitis, those of the genitourinary and upper respiratory tracts, and skin infections. Lomefloxacin, like other fluoroquinolones, is mutagenic and the formation of reactive oxygen species

Determination of four fluoroquinolone antibiotics in tap water in Guangzhou and Macao.

Yiruhan et al.

Environmental pollution (Barking, Essex : 1987), 158(7), 2350-2358 (2010-05-04)

Four fluoroquinolone antibiotics (norfloxacin, ciprofloxacin, lomefloxacin, and enrofloxacin) in tap water in Guangzhou and Macao were analyzed using high performance liquid chromatography fluorescence detection. The results showed that all target antibiotics were detected in high rate both in Guangzhou (77.5%)

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Global Trade Item Number

SKU	GTIN
L2906-10G	04061833611692
L2906-1G	04061833950579

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