The compound should be dissolved initially at 50mg/mL in a 2:1 mixture of Formic acid and water, respectively. Once dissolved, the stock can be diluted in a buffer or culture medium. This is not a sterile product. Stock solutions should be filter sterilized prior to adding to sterile medium.
H9636
Hypoxanthine
powder, suitable for cell culture, BioReagent
Synonym(s):
6-Hydroxypurine
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About This Item
Empirical Formula (Hill Notation):
C5H4N4O
CAS Number:
Molecular Weight:
136.11
NACRES:
NA.75
PubChem Substance ID:
UNSPSC Code:
12352207
EC Number:
200-697-3
MDL number:
Beilstein/REAXYS Number:
5811
Pricing and availability is not currently available.
Product Name
Hypoxanthine, powder, BioReagent, suitable for cell culture
product line
BioReagent
Quality Segment
assay
≥99%
form
powder
technique(s)
cell culture | mammalian: suitable
SMILES string
O=C1NC=Nc2nc[nH]c12
InChI
1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)
InChI key
FDGQSTZJBFJUBT-UHFFFAOYSA-N
General description
Hypoxanthine (6-hydroxypurine), a purine derivative is a naturally occurring compound. It is the deaminated form of adenine and a breakdown product of adenosine monophosphate (AMP).
Application
Hypoxanthine has been used:
- as a supplement in HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid) -buffered Roswell park memorial institute (RPMI) to culture Plasmodium falciparum strain IT/FCR3
- in the preparation of Dulbecco′s modified eagle′s medium (DMEM) + MXH for the selection of chimeric modified vaccinia virus ankara (MVA)
- to generate superoxide anions[1]
- to prepare hybridoma selection and maintenance media.
Hypoxanthine is a nutrient additive for a variety of cell culture applications involving bacterial, parasite (Plasmodium falciparum) and animal cells. Hypoxanthine is a component of selection media used in hybridoma technologies.
Biochem/physiol Actions
Hypoxanthine is capable of stimulating cell death. It can also induce reactive oxygen species (ROS). It results in endothelial dysfunction via apoptosis, stimulated by oxidative stress.
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This Item | |||
|---|---|---|---|
| technique(s) cell culture | mammalian: suitable | technique(s) - | technique(s) - | technique(s) - |
| product line BioReagent | product line - | product line - | product line - |
| Quality Level 200 | Quality Level 100 | Quality Level - | Quality Level 200, 300 |
| assay ≥99% | assay ≥99% (HPLC) | assay - | assay ≥99.0% |
| form powder | form solid | form - | form powder |
hybridoma selection agent, IMP salvage pathway, inositol monophosphate, IMP precursor, Hypoxanthine-guanine phosphoribosyltransferase | - | - | - |
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Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| H9636-1G | 04061833812839 |
| H9636-25G | 04061833812877 |
| H9636-5G | 04061833812884 |
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What is the solubility of HYPOXANTHINE in water and How to dissolve HYPOXANTHINE in water for cell culture.
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