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F5631

Fucoidan from Fucus vesiculosus

Crude

Synonym(s):

Fucoidin

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About This Item

CAS Number:
9072-19-9
UNSPSC Code:
12352201
NACRES:
NA.25
MDL number:
MFCD00131109
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biological source

algae (Fucus Vesiculosus)

Quality Level

200

form

powder

quality

Crude

color

light yellow to brown

solubility

H2O: 10 mg/mL, clear to hazy, faintly yellow to brownish-yellow

cation traces

Ca: ≤1%, Na: ≤ 8% (ICP)

storage temp.

room temp

General description

Fucoidan is a fucose-rich, sulfated polysaccharide isolated from several species of brown seaweed.

Application

Fucoidan from Fucus vesiculosus may be used as a biological response modifier and as a potential therapeutic agent with a wide range of biological activities. It may be used to study its pharmacokinetics, safety, efficacy and methods of delivery as a potential anticancer, anti-immune and anti-inflammatory agent. Fucoidan may be used to assess its potential and formulations for tissue engineering applications.

Biochem/physiol Actions

Studies of fucoidan have found it to have a broad variety of biological activities including antitumor and antiangogenic activities, immunomodulatory, anti-inflammatory, anticoagulant, antithrombotic, and antioxidant activities. Fucoidan induces macrophage activation with subsequently activates mitogen activated protein kinases (MAPKs) and results in natural killer cell proliferation. Fucoidan acts as a nonselective selectin blocker and has been shown to induce apoptosis and suppress angiogenesis.

Preparation Note

Prepared by a modification of the method of Black, W.A.P., et al., J. Sci. Food Agri., 3, 122 (1952).

Other Notes

To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

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This Item
F8315F8190F8065
Fucoidan from Fucus vesiculosus Crude

Sigma-Aldrich

F5631

Fucoidan from Fucus vesiculosus

Fucoidan from Undaria pinnatifida ≥95%

Sigma-Aldrich

F8315

Fucoidan from Undaria pinnatifida

Fucoidan from Fucus vesiculosus ≥95%

Sigma-Aldrich

F8190

Fucoidan from Fucus vesiculosus

Fucoidan from Macrocystis pyrifera ≥85%

Sigma-Aldrich

F8065

Fucoidan from Macrocystis pyrifera

biological source

algae (Fucus Vesiculosus)

biological source

algae (Undaria pinnatifida)

biological source

algae (Fucus Vesiculosus)

biological source

algae (Macrocystis pyrifera)

solubility

H2O: 10 mg/mL, clear to hazy, faintly yellow to brownish-yellow

solubility

water: 10 mg/mL, clear to slightly hazy, colorless to faintly yellow

solubility

water: 10 mg/mL, clear, colorless to faintly yellow

solubility

water: 10 mg/mL, clear to hazy, colorless to very faintly brown

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

powder

form

powder

form

powder

form

powder

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

color

light yellow to brown

color

white to off-white

color

light yellow

color

white to brown

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000536912
0000498848
0000536912
0000498848
0000463063

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Wiktoria Blaszczak et al.
Molecules (Basel, Switzerland), 23(12) (2018-12-14)
Fucoidans have been reported to exert anticancer effects with simultaneous low toxicity against healthy tissue. That correlation was observed in several cancer models, however, it has never been investigated in head and neck cancer before. To magnify the efficacy of
Celina Maria P Guerra Dore et al.
Carbohydrate polymers, 91(1), 467-475 (2012-10-10)
Fucan (SV1) sulfated polysaccharides from the brown algae Sargassum vulgare were extracted, fractionated in acetone and examined with respect to chemical composition, anticoagulant, anti-inflammatory, antithrombotic effects and cellular proliferation. These polysaccharides contain low levels of protein, high level of carbohydrate
Suwaree Kitikiew et al.
Fish & shellfish immunology, 34(1), 280-290 (2012-12-04)
In this study, we examined the effect of fucoidan on the immune response of white shrimp Litopenaeus vannamei and its resistance against Vibrio alginolyticus infection. Fucoidan induced degranulation, caused changes in the cell morphology, and increased activation of prophenoloxidase (proPO)
View All Related Papers

Global Trade Item Number

SKUGTIN
F5631-1G04061826107652
F5631-500MG04061832628912

Questions

1–8 of 8 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. What is the solubility of Product F5631, Fucoidan from Fucus vesiculosus?

    1 answer

    1. The F5631 is water-soluble. It is tested for solublity in water at 10mg/mL; this yields a clear to hazy, yellow to amber solution.

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  4. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  5. Is there information about the structure of Product F5631, Fucoidan from Fucus vesiculosus?

    1 answer

    1. In general, fucoidin is a branched polymer of L-fucose monosulfate joined predominately by 1,2 linkages. Fucoidin is also known in the literature as fucan. The properties are discussed further by Bernardi and Springer in J. Biol. Chem, 237, 75-80 (1962); the title of the article is "Properties of highly purified fucan".

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  6. What is the molecular weight of Product F5631, Fucoidan from Fucus vesiculosus?

    1 answer

    1. The molecular weight of the F5631 is assayed on a lot-by-lot basis. The molecular weight will be reported on the certificate of analysis for each lot of product.

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  7. What is the purity of Product F5631, Fucoidan from Fucus vesiculosus?

    1 answer

    1. The F5631 is not tested for purity or to identify possible impurities. It is a crude fucoidan from Fucus vesiculosus.

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  8. How does the storage temperature relate to shipping conditions?

    1 answer

    1. The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.

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