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Chaperonin 60 from Escherichia coli

Name: Chaperonin 60 from <I>Escherichia coli</I>
Brand: SIGMA

>95% (SDS-PAGE), recombinant, expressed in E. coli overproducing strain, lyophilized powder

Synonym(s):

Cpn60, GroEL

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About This Item

UNSPSC Code:

12352200

NACRES:

NA.32

MDL number:

MFCD00163256

Form:

lyophilized powder

Assay:

>95% (SDS-PAGE)

Biological source:

Escherichia coli

Recombinant:

expressed in E. coli overproducing strain

Pricing and availability is not currently available.

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Properties

biological source

Escherichia coli

Quality Segment

200

recombinant

expressed in E. coli overproducing strain

assay

>95% (SDS-PAGE)

form

lyophilized powder

technique(s)

electron microscopy: suitable, mass spectrometry (MS): suitable

suitability

passes test (Refolding (w/GroES))

UniProt accession no.

P10809

storage temp.

2-8°C

Gene Information

human ... HSPD1(3329)

Description

General description

Research area: Cell Signaling

Chaperonin 60 (GroEL) and chaperonin 10 (GroES) belong to the ubiquitous family of heat-shock molecular chaperones found in prokaryotes and in eukaryotic organelles.

Application

Chaperonin 60 from Escherichia coli has been used:

in mass spectroscopy
in cryo-electron microscopy imaging as control for testing particle distribution
as standard in infrared spectrum measurements
as a protein sample for stability assessment and characterization studies using differential mobility analysis (DMA) and cryo-electron microscopy (cryo-EM).

Biochem/physiol Actions

Apart from its role in facilitating protein folding, chaperonin 60 (Cpn60) serves as an extracellular signaling protein, showing functional similarities to certain proinflammatory cytokines. Furthermore, Cpn60 contributes to the inhibition of lipid accumulation and adipogenesis during the initial stages of cellular differentiation, thereby exerting anti-obesity effects.

Packaging

Package size based on protein content.

Physical form

Lyophilized powder containing Tris buffer salts, potassium chloride, magnesium chloride, dithiothreitol, and trehalose as stabilizer.

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This Item	C7438	MSST0007	M0630
Sigma-Aldrich C7688 Chaperonin 60 from Escherichia coli	Sigma-Aldrich C7438 Chaperonin 10 from Escherichia coli	Sigma-Aldrich MSST0007 SILu^™Prot CLU Clusterin human	Sigma-Aldrich M0630 Myoglobin from equine skeletal muscle
recombinant expressed in E. coli overproducing strain	recombinant expressed in E. coli overproducing strain	recombinant expressed in HEK 293 cells	recombinant -
technique(s) electron microscopy: suitable, mass spectrometry (MS): suitable	technique(s) activity assay: suitable	technique(s) mass spectrometry (MS): suitable	technique(s) mass spectrometry (MS): suitable
biological source Escherichia coli	biological source Escherichia coli	biological source human	biological source equine skeletal muscle
assay >95% (SDS-PAGE)	assay ≥95.0% (SDS-PAGE)	assay ≥98% (SDS-PAGE)	assay 95-100%
form lyophilized powder	form lyophilized powder	form lyophilized powder	form essentially salt-free, lyophilized powder
suitability passes test (Refolding (w/GroES))	suitability -	suitability -	suitability -

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number

0000451681

0000358973

0000235438

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Global Trade Item Number

SKU	GTIN
C7688-1MG	04061826674260

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