It is recommended to aliquot and store frozen at -20°C following reconstitution. Stock solutions are stable for up to 3 months at -20°C.
C2992
CFTR Inhibitor-172
≥98% (HPLC), powder, CFTR inhibitor
Synonym(s):
5-[(4-Carboxyphenyl)methylene]-2-thioxo-3-[(3-trifluoromethyl)phenyl-4-thiazolidinone
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About This Item
Empirical Formula (Hill Notation):
C18H10F3NO3S2
CAS Number:
Molecular Weight:
409.40
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Pricing and availability is not currently available.
Product Name
CFTR(inh)-172, ≥98% (HPLC), powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
yellow
solubility
DMSO: ≥10 mg/mL, H2O: insoluble
storage temp.
2-8°C
SMILES string
OC(=O)c1ccc(cc1)\C=C2\SC(=S)N(C2=O)c3cccc(c3)C(F)(F)F
InChI
1S/C18H10F3NO3S2/c19-18(20,21)12-2-1-3-13(9-12)22-15(23)14(27-17(22)26)8-10-4-6-11(7-5-10)16(24)25/h1-9H,(H,24,25)/b14-8+
InChI key
JIMHYXZZCWVCMI-RIYZIHGNSA-N
Application
CFTR(inh)-172 has been used to specifically inhibit cystic fibrosis transmembrane conductance regulator (CFTR) activity. It is also used as a CFTR inhibitor Inh-172 to treat forskolin and IBMX.
Biochem/physiol Actions
CFTR(inh)-172 is an inhibitor of the cystic fibrosis transmembrane conductance regulator (CFTR).
CFTR(inh)-172 is an inhibitor of the cystic fibrosis transmembrane conductance regulator (CFTR). With a Ki = 300 nM,. CFTR(inh)-172 leads to rapid, reversible and voltage-independent inhibition; it is an antidiarrheal agent in animals. CTFR(inh)-172 may be a useful tool to study animal models of cystic fibrosis and intestinal fluid loss in cholera and other secretory diarrheas. CTFR(inh)-172 is structurally-unrelated to known, but non-specific CFTR inhibitors DPC, NPPB (Cat. No. N4779) and Glibenclamide.
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This Item | |||
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| form powder | form powder | form powder | form powder |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: ≥10 mg/mL, H2O: insoluble | solubility DMSO: ≥15 mg/mL | solubility DMSO: 10 mg/mL, clear | solubility DMSO: 20 mg/mL, clear |
| color yellow | color white to tan | color white to beige | color white to beige |
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Storage Class
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| C2992-5MG | 04061833484968 |
| C2992-25MG | 04061833484951 |
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Bonjour, J'aurai voulu connaitre la stabilité de l'inhibiteur après plusieurs mois après qu'elle soit stocké sous forme de solvant. Merci
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