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8-(4-Chlorophenylthio)adenosine-3′,5′-cyclic Monophosphorothioate, Rp-isomer sodium salt

Name: 8-(4-Chlorophenylthio)adenosine-3′,5′-cyclic Monophosphorothioate, Rp-isomer sodium salt
Brand: SIGMA

≥99% (HPLC), solid

Synonym(s):

Rp-8-CPT-cAMPS

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₁₄ClN₅O₅PS₂Na

CAS Number:

129735-01-9

Molecular Weight:

509.86

NACRES:

NA.77

PubChem Substance ID:

24892271

UNSPSC Code:

41106305

MDL number:

MFCD04113743

Assay:

≥99% (HPLC)

Form:

solid

Quality level:

200

Pricing and availability is not currently available.

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Properties

biological source

synthetic (organic)

Quality Level

200

assay

≥99% (HPLC)

form

solid

packaging

vial of 5 μmol

storage temp.

−20°C

SMILES string

[Na+].Nc1ncnc2n([C@@H]3O[C@@H]4COP([S-])(=O)O[C@H]4[C@H]3O)c(Sc5ccc(Cl)cc5)nc12

InChI

1S/C16H15ClN5O5PS2.Na/c17-7-1-3-8(4-2-7)30-16-21-10-13(18)19-6-20-14(10)22(16)15-11(23)12-9(26-15)5-25-28(24,29)27-12;/h1-4,6,9,11-12,15,23H,5H2,(H,24,29)(H2,18,19,20);/q;+1/p-1/t9-,11-,12-,15-,28?;/m1./s1

InChI key

AWXMSJRRXLCVMW-JVSRKQJHSA-M

Description

Biochem/physiol Actions

Lipophilic analog of the competitive inhibitor of protein kinase A (cyclic AMP antagonist).

Features and Benefits

This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item	C240	C8988	SML1614
Sigma-Aldrich C0735 8-(4-Chlorophenylthio)adenosine-3′,5′-cyclic Monophosphorothioate, Rp-isomer sodium salt	Sigma-Aldrich C240 8-(4-Chlorophenylthio)-guanosine 3′,5′-cyclic monophosphorothioate, Rp Isomer triethylammonium salt	Sigma-Aldrich C8988 8-(4-Chlorophenylthio)-2′-O-methyladenosine 3′,5′-cyclic monophosphate monosodium hydrate	Sigma-Aldrich SML1614 Rp-8-Br-cGMPS sodium salt
assay ≥99% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form solid	form solid	form powder	form lyophilized solid
Quality Level 200	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
packaging vial of 5 μmol	packaging -	packaging -	packaging -
biological source synthetic (organic)	biological source synthetic	biological source -	biological source -

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Cascade Signals of Papaverine Inhibiting LPS-Induced Retinal Microglial Activation.

Ting Zhou et al.

Journal of molecular neuroscience : MN, 68(1), 111-119 (2019-03-11)

Studies have shown that papaverine can inhibit lipopolysaccharide (LPS)-induced microglial activation. The retinal primary microglia of newborn SD rats were isolated and purified, and a LPS-induced microglia activation model was established. The protein phosphorylation level of the signaling pathway was

Mediation of hippocampal mossy fiber long-term potentiation by cyclic AMP.

M G Weisskopf et al.

Science (New York, N.Y.), 265(5180), 1878-1882 (1994-09-23)

Repetitive activation of hippocampal mossy fibers evokes a long-term potentiation (LTP) of synaptic responses in pyramidal cells in the CA3 region that is independent of N-methyl-D-aspartate receptor activation. Previous results suggest that the site for both the induction and expression

Transient Activation of GABAB Receptors Suppresses SK Channel Currents in Substantia Nigra Pars Compacta Dopaminergic Neurons.

Chad M Estep et al.

PloS one, 11(12), e0169044-e0169044 (2016-12-31)

Dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc) are richly innervated by GABAergic neurons. The postsynaptic effects of GABA on SNc DA neurons are mediated by a mixture of GABAA and GABAB receptors. Although activation of GABAA receptors

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Global Trade Item Number

SKU	GTIN
C0735-1VL	04061838171979

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