A5282

DL-2-Amino-5-phosphonopentanoic acid

≥98% (TLC), solid, NMDA receptor antagonist

• Synonym(s): 5-Phosphono-DL-norvaline, DL-2-Amino-5-phosphonovaleric acid, AP-5, APV
• Empirical Formula (Hill Notation): C₅H₁₂NO₅P
• CAS Number: 76326-31-3
• Molecular Weight: 197.13
• NACRES: NA.32
• PubChem Substance ID: 24277950
• UNSPSC Code: 12352106
• MDL number: MFCD00010515
• Beilstein/REAXYS Number: 2446389
• Form: solid
• Quality level: 200

Properties

• Product Name: DL-2-Amino-5-phosphonopentanoic acid, solid
• form: solid
• Quality Level: 200
• color: white
• solubility: 0.1 M NaOH: 4 mg/mL, H₂O: 5.6 mg/mL, organic solvents: insoluble
• SMILES string: NC(CCCP(O)(O)=O)C(O)=O
• InChI: 1S/C5H12NO5P/c6-4(5(7)8)2-1-3-12(9,10)11/h4H,1-3,6H2,(H,7,8)(H2,9,10,11)
• InChI key: VOROEQBFPPIACJ-UHFFFAOYSA-N
• Gene Information: rat ... Grik1(29559), Grin2a(24409), Grin2b(24410)

Description

Application

DL-2-Amino-5-phosphonopentanoic acid has been used:

• in the inactivation of N-methyl-D-aspartate (NMDA)-mediated synapses[1]
• used in growth medium for inhibition of electrical activity in the neuronal network
• used to isolate N-methyl-D-aspartate receptors (NMDAR) or α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)-mediated currents were isolated using this product
• used in double distilled water to compare its NMDA antagonistic action with that of prion protein (PrPC)[2]

Biochem/physiol Actions

Anticonvulsant; potent and selective NMDA receptor antagonist.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Disclaimer

Hygroscopic

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves