A3109

A-803467

≥98% (HPLC), Nav1.8 sodium channel blocker, powder

• Synonym(s): 5-4(-Chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-carboxamide
• Empirical Formula (Hill Notation): C₁₉H₁₆NO₄Cl
• CAS Number: 944261-79-4
• Molecular Weight: 357.79
• UNSPSC Code: 12352200
• PubChem Substance ID: 329770815
• NACRES: NA.77
• MDL number: MFCD10574689
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Product Name: A-803467, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to tan
• solubility: DMSO: >10 mg/mL
• originator: Abbott
• storage temp.: room temp
• SMILES string: COc1cc(NC(=O)c2ccc(o2)-c3ccc(Cl)cc3)cc(OC)c1
• InChI: 1S/C19H16ClNO4/c1-23-15-9-14(10-16(11-15)24-2)21-19(22)18-8-7-17(25-18)12-3-5-13(20)6-4-12/h3-11H,1-2H3,(H,21,22)
• InChI key: VHKBTPQDHDSBSP-UHFFFAOYSA-N

Description

General description

A-803467 inhibits spontaneous and evoked action potentials in sensory neurons. It exhibits antinociceptive effects. A-803467 decreases the firing in spinal dorsal horn neurons in vivo.

The small molecule A-803467 is a potent and selective Nav1.8 sodium channel blocker. Nav1.8 is a tetrodotoxin-resistant (TTX-R) sodium channel that contributes to pain sensation by transmitting pain stimuli in peripheral sensory neurons; blockage of this channel by A-803467 reduces pain with varying effectiveness in a number of different models.[1][2] A-803467 has been used to further understand the role of Nav1.8 in transmitting pain stimuli and also can be used as an analgesic.[2]

Biochem/physiol Actions

A-803467 blocks Nav1.8 in both half-maximal inactive and resting states with an IC₅₀ of 8 nM and IC₅₀ of 79 nM, respectively. A-803467 is over 100-fold more selective vs. human Nav1.2, 1.3, 1.5 and 1.7.[1]

Features and Benefits

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable