A0912
D-Ala-D-Ala
≥99%
Synonym(s):
D-alanyl-D-Alanine
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About This Item
Empirical Formula (Hill Notation):
C6H12N2O3
CAS Number:
Molecular Weight:
160.17
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.26
MDL number:
Pricing and availability is not currently available.
Product Name
D-Ala-D-Ala,
assay
≥99%
Quality Level
form
powder
color
white to off-white
storage temp.
−20°C
SMILES string
C[C@@H](N)C(=O)N[C@H](C)C(O)=O
InChI
1S/C6H12N2O3/c1-3(7)5(9)8-4(2)6(10)11/h3-4H,7H2,1-2H3,(H,8,9)(H,10,11)/t3-,4-/m1/s1
InChI key
DEFJQIDDEAULHB-QWWZWVQMSA-N
Application
- Binding Mode-Based Physicochemical Screening Method Using d-Ala-d-Ala Silica Gel and Chemical Modification Approach to Facilitate Discovery of New Macrolactams, Banglactams A and B, from Nonomuraea bangladeshensis K18-0086.: Describes a novel screening method employing D-Ala-D-Ala silica gel to discover new macrolactams with potential antibacterial properties. This technique aids in identifying compounds that inhibit bacterial cell wall synthesis (Kimishima et al., 2024).
Biochem/physiol Actions
D-Ala-D-Ala is found in the stem termini of peptidoglycan side-chain pentapeptide found in the cell walls of gram positive bacteria. The D-ala-d-ala stem termini is the site of interaction of glycopeptide antibiotics such as vancomycin and teicoplanin. D-ala-D-ala is a substrate used to study kinetics of UDPMurNAc-tripeptide D-alanyl-D-alanine-adding (ligase) enzyme.
D-Ala-D-Ala, a terminus moiety of bacterial peptidoglycans, is used for affinity chromatography and binding mechanism studies of antibiotics such as teicoplanin, ristocetin, vancomycin.
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This Item | |||
|---|---|---|---|
| form powder | form powder | form - | form powder |
| assay ≥99% | assay ≥98% (TLC) | assay ≥98.0% (HPLC) | assay ≥95% |
| storage temp. −20°C | storage temp. - | storage temp. 2-8°C | storage temp. −20°C |
| color white to off-white | color white | color - | color - |
| Quality Level 200 | Quality Level 200 | Quality Level 100 | Quality Level 100 |
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Vivek K Mutalik et al.
PLoS biology, 18(10), e3000877-e3000877 (2020-10-14)
Bacteriophages (phages) are critical players in the dynamics and function of microbial communities and drive processes as diverse as global biogeochemical cycles and human health. Phages tend to be predators finely tuned to attack specific hosts, even down to the
Maulik N Thaker et al.
Antimicrobial agents and chemotherapy, 59(3), 1405-1410 (2014-12-17)
Vancomycin-resistant enterococci (VRE) are notorious clinical pathogens restricting the use of glycopeptide antibiotics in the clinic setting. Routine surveillance to detect VRE isolated from patients relies on PCR bioassays and chromogenic agar-based test methods. In recent years, we and others
Gareth A Prosser et al.
Antimicrobial agents and chemotherapy, 60(10), 6091-6099 (2016-08-03)
The increasing global prevalence of drug resistance among many leading human pathogens necessitates both the development of antibiotics with novel mechanisms of action and a better understanding of the physiological activities of preexisting clinically effective drugs. Inhibition of peptidoglycan (PG)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| A0912-1G | 04061826681220 |
| A0912-250MG | 04061832883250 |