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62962

L-α-Lysophosphatidylcholine

egg yolk, ≥99.0% (TLC)

Synonym(s):

3-sn-Lysophosphatidylcholine, L-α-Lysolecithin

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About This Item

UNSPSC Code:
51321705
NACRES:
NA.25
MDL number:
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biological source

egg yolk

description

zwitterionic

assay

≥99.0% (TLC)

form

powder or solid

composition

16:0, ~69% (fatty acid), 18:0, ~27% (fatty acid), 18:1, ~3% (fatty acid)

solubility

chloroform/methanol: 50 mg/mL, clear, colorless to very faintly yellow

functional group

phospholipid

lipid type

phosphoglycerides

shipped in

wet ice

storage temp.

−20°C

Application


  • The activation mode of the mechanosensitive ion channel, MscL, by lysophosphatidylcholine differs from tension-induced gating: L-α-LPC is explored for its unique interaction with ion channels, suggesting its potential as a tool for studying channel mechanics and developing new therapeutic strategies for diseases linked to cellular mechanics (Mukherjee et al., 2014).

  • Aerosol delivery of an enhanced helper-dependent adenovirus formulation to rabbit lung using an intratracheal catheter: The use of L-α-LPC in enhancing the delivery of gene therapy vectors via aerosol demonstrates its utility in improving the efficiency of gene therapies, particularly for respiratory diseases (Koehler et al., 2005).

Biochem/physiol Actions

3-sn-Lysophosphatidylcholine, besides contributing to the positive curvature of membranes [1], inhibits SNARE complex disassembly in vitro and in rat nerve terminals and exocrine pancrease [2].

Other Notes

Preparation of demembranated frog sperm chromatin[3]

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This Item
62963L0906L4129
form

powder or solid

form

-

form

lyophilized powder

form

powder

assay

≥99.0% (TLC)

assay

≥98.0% (10 mg phospholipid per ml CHCl3, TLC)

assay

≥99%

assay

≥99%

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

biological source

egg yolk

biological source

soybean

biological source

soybean

biological source

egg yolk

description

zwitterionic

description

zwitterionic

description

zwitterionic

description

zwitterionic

solubility

chloroform/methanol: 50 mg/mL, clear, colorless to very faintly yellow

solubility

-

solubility

-

solubility

-


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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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Fengfeng Lu et al.
Neuroscience bulletin, 35(3), 434-446 (2019-01-27)
The obstacle to successful remyelination in demyelinating diseases, such as multiple sclerosis, mainly lies in the inability of oligodendrocyte precursor cells (OPCs) to differentiate, since OPCs and oligodendrocyte-lineage cells that are unable to fully differentiate are found in the areas
Nuclear envelope assembly following mitosis.
R Pfaller et al.
Methods in enzymology, 219, 60-72 (1992-01-01)
Beibei Duan et al.
Molecules (Basel, Switzerland), 26(6) (2021-04-04)
Fat globule size and phospholipid (PL) content in human milk (HM) were investigated. HM was classified into three groups depending on fat content (A < B < C). PL content (mg/100 g HM) was significantly higher in the C group



Global Trade Item Number

SKUGTIN
62962-50MG04061832793382

Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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