Skip to Content
Merck

Key Documents

View All Documentation

Skip To

S8951

SR11237

≥98% (HPLC)

Synonym(s):

4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dioxolan-2-yl]-benzoic acid, BMS 188649, BMS649

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View
Pack SizeSKUAvailabilityPrice

About This Item

Empirical Formula (Hill Notation):
C24H28O4
CAS Number:
146670-40-8
Molecular Weight:
380.48
NACRES:
NA.77
PubChem Substance ID:
329824615
UNSPSC Code:
12352200
MDL number:
MFCD00864137
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
Pricing and availability is not currently available.
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: >28 mg/mL (warmed)

storage temp.

2-8°C

SMILES string

CC1(C)CCC(C)(C)c2cc(ccc12)C3(OCCO3)c4ccc(cc4)C(O)=O

InChI

1S/C24H28O4/c1-22(2)11-12-23(3,4)20-15-18(9-10-19(20)22)24(27-13-14-28-24)17-7-5-16(6-8-17)21(25)26/h5-10,15H,11-14H2,1-4H3,(H,25,26)

InChI key

ZZUKALQMHNSWTK-UHFFFAOYSA-N

Application

SR11237 may be used in RXR-mediated cell signaling studies.

Biochem/physiol Actions

SR11237 and other ligands of retinoid X receptor (RXR) activate various nuclear receptors during development process. This produces malformations in Xenopus embryos, involving the anterior-posterior axis.1
SR11237 is a pan retinoid X receptor (RXR) agonist.
SR11237 is a selective pan retinoid X receptor (RXR) agonist with no retinoid A receptor (RAR) activity.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item
SML2015SML0397SML0282
SR11237 ≥98% (HPLC)

Sigma-Aldrich

S8951

SR11237

MM11253 ≥98% (HPLC)

Sigma-Aldrich

SML2015

MM11253

DR2313 ≥98% (HPLC)

Sigma-Aldrich

SML0397

DR2313

Bexarotene ≥98% (HPLC)

Sigma-Aldrich

SML0282

Bexarotene

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

DMSO: >28 mg/mL (warmed)

solubility

DMSO: 2 mg/mL, clear

solubility

H2O: >2 mg/mL (warmed)

solubility

DMSO: ≥15 mg/mL (warmed)

color

white to off-white

color

white to beige

color

white to beige

color

white to beige

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000529067
0000529067
0000206460
0000206461
031M4607V

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Detection of a receptor-ligand non-covalent complex using a triple quadrupole mass spectrometer.
Johan Lengqvist et al.
Rapid communications in mass spectrometry : RCM, 16(20), 2003-2006 (2002-10-04)
G J Gendimenico et al.
The Journal of investigative dermatology, 102(5), 676-680 (1994-05-01)
We evaluated SR11237, a retinoid X receptor (RXR)-specific compound, for its pharmacologic effects on cell differentiation in F9 embryonal carcinoma cells and rhino mouse epidermis. SR11237 can cause RXR/RXR homodimers to form and transactivate a reporter gene containing a RXR-response
Guo-quan Chen et al.
International journal of cancer, 99(2), 171-178 (2002-04-30)
Epidemiological and animal studies have demonstrated that vitamin A and its natural and synthetic derivatives, retinoids, are effective agents in preventing the development of tobacco-associated cancers. Unfortunately, clinical trials of retinoids on cigarette smokers have shown lack of efficacy in
View All Related Papers

Global Trade Item Number

SKUGTIN
S8951-25MG04061832954684
S8951-5MG04061832954691

Questions

Reviews

No rating value

Active Filters