76157

(4R)-4-Hydroxy-L-glutamic acid

≥98.0% (TLC)

• Synonym(s): erythro-(4R)-4-Hydroxy-L-glutamic acid, H-(2S,4R)-γ-Hydroxy-Glu-OH
• Empirical Formula (Hill Notation): C₅H₉NO₅
• CAS Number: 2485-33-8
• Molecular Weight: 163.13
• NACRES: NA.28
• PubChem Substance ID: 329766558
• UNSPSC Code: 12352202
• MDL number: MFCD00672375
• Beilstein/REAXYS Number: 1725871

Properties

• Product Name: (4R)-4-Hydroxy-L-glutamic acid, ≥98.0% (TLC)
• Quality Segment: 100
• assay: ≥98.0% (TLC)
• form: powder
• optical activity: [α]/D 20.5±1.5°, c = 1 in H₂O
• color: white
• mp: 171 °C
• storage temp.: −20°C
• SMILES string: N[C@@H](C[C@@H](O)C(O)=O)C(O)=O
• InChI: 1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/t2-,3+/m0/s1
• InChI key: HBDWQSHEVMSFGY-STHAYSLISA-N

Description

Biochem/physiol Actions

(4R)-4-Hydroxy-L-glutamic acid or (2S,4R)-4-hydroxyglutamate was shown to activate the metabotropic glutamate receptors, mGlu1a, mGlu2, and mGlu8a in a dose-dependent manner. [1]

Substrate for aminotransferase[2]; pharmacological characterization at human glutamate transporter subtypes 1-3[3]; for studying structure-activity relationships (SAR) for ionotropic and metabotropic glutamate receptors[4].

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Safety Information

• Storage Class: 11 - Combustible Solids
• flash_point_f: Not applicable
• flash_point_c: Not applicable