Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
S6942
Staurosporine solution from Streptomyces sp.
Ready Made Solution, 1 mM in DMSO (100 μg/214 μL)
Synonym(s):
Antibiotic AM-2282
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
| Pack Size | SKU | Availability | Price |
|---|
About This Item
Assay:
>98% (HPLC)
Quality level:
Pricing and availability is not currently available.
Product Name
Staurosporine solution from Streptomyces sp., Ready Made Solution, 1 mM in DMSO (100 μg/214 μL)
Quality Level
assay
>98% (HPLC)
concentration
1 mM in DMSO (100 μg/214 μL)
technique(s)
cell culture | mammalian: suitable
antibiotic activity spectrum
fungi
mode of action
enzyme | inhibits
shipped in
wet ice
storage temp.
−20°C
General description
Chemical structure: indol derivative
Application
Staurosporine solution from Streptomyces sp. was used to study the effect of PKC inhibition on signaling mediated by angiotensin II.3 It was used to induce cell death in Jurkat cells.4
Biochem/physiol Actions
Potent cell-permeable inhibitor of protein kinase C. Induces apoptosis in Jurkat cells.
Potent inhibitor of phospholipid/calcium-dependent protein kinase. Inhibits the upregulation of VEGF expression in tumor cells.
1 of 1
This Item | |||
|---|---|---|---|
| assay >98% (HPLC) | assay ≥98% (HPLC) | assay ≥95% (HPLC) | assay ≥97% (HPLC) |
| Quality Level 300 | Quality Level 300 | Quality Level 300 | Quality Level 100 |
| technique(s) cell culture | mammalian: suitable | technique(s) - | technique(s) - | technique(s) - |
| storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −70°C |
| shipped in wet ice | shipped in - | shipped in - | shipped in wet ice |
| antibiotic activity spectrum fungi | antibiotic activity spectrum neoplastics | antibiotic activity spectrum fungi | antibiotic activity spectrum - |
Storage Class
10 - Combustible liquids
flash_point_f
188.6 °F - closed cup
flash_point_c
87 °C - closed cup
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Yu-Jung Lee et al.
American journal of physiology. Renal physiology, 292(1), F340-F350 (2006-08-10)
Vasopressin and angiotensin II (ANG II) play a major role in renal water and Na(+) reabsorption. We previously demonstrated that ANG II AT(1) receptor blockade decreases dDAVP-induced water reabsorption and AQP2 levels in rats, suggesting cross talk between these two
Dale W Hailey et al.
Cell, 141(4), 656-667 (2010-05-19)
Starvation-induced autophagosomes engulf cytosol and/or organelles and deliver them to lysosomes for degradation, thereby resupplying depleted nutrients. Despite advances in understanding the molecular basis of this process, the membrane origin of autophagosomes remains unclear. Here, we demonstrate that, in starved
G Warnes et al.
Cytometry. Part A : the journal of the International Society for Analytical Cytology, 79(3), 181-191 (2011-01-22)
The standard method of distinguishing apoptotic and oncotic cells has been by microscopic analysis of nuclei and cell membrane morphology. Thus a rapid test for analyzing large numbers of cells in the study of cell necrobiology has not been possible
Global Trade Item Number
| SKU | GTIN |
|---|---|
| S6942-100UL | 04061837899089 |
| S6942-200UL | 04061836959708 |
| S6942-110UL | 04061837899096 |
-
What is the Department of Transportation shipping information for this product?
1 answer-
Helpful?
-
-
What concentration of Staurosporin is used for the release of microparticles from apoptotic cells?
1 answer-
Staurosporin can induce apopotosis in Jurkat cells (106/ml) at 1 ug/ml following a 1-2 hour incubation at 37°C. For the release of microparticles from apoptotic Jurkat cells, use staurosporin at 1 uM for 107 cells/ml. Please see the reference below for further details. Apoptosis 15(5):586, 2010.
Helpful?
-