This product is soluble in water at 50 mg/mL. Similar rates would be expected in PBS; a 20 mg/mL stock solution should not be problematic. Prepare fresh and use immediately; protect from light. Please see the link below to review additional information available in the product datasheet:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/427/584/s2671pis.pdf
S2671
Suramin sodium salt
≥98% (HPLC)
Synonym(s):
Suramine sodium salt
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About This Item
Empirical Formula (Hill Notation):
C51H34N6Na6O23S6
CAS Number:
Molecular Weight:
1429.17
UNSPSC Code:
12352201
NACRES:
NA.25
PubChem Substance ID:
EC Number:
204-949-3
Beilstein/REAXYS Number:
3694087
MDL number:
Pricing and availability is not currently available.
Quality Segment
assay
≥98% (HPLC)
form
powder
impurities
<15% water (Karl Fischer)
color
white to light brown
solubility
H2O: >10 mg/mL
SMILES string
[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].Cc1ccc(cc1NC(=O)c2cccc(NC(=O)Nc3cccc(c3)C(=O)Nc4cc(ccc4C)C(=O)Nc5ccc(c6cc(cc(c56)S([O-])(=O)=O)S([O-])(=O)=O)S([O-])(=O)=O)c2)C(=O)Nc7ccc(c8cc(cc(c78)S([O-])(=O)=O)S([O-])(=O)=O)S([O-])(=O)=O
InChI
1S/C51H40N6O23S6.6Na/c1-25-9-11-29(49(60)54-37-13-15-41(83(69,70)71)35-21-33(81(63,64)65)23-43(45(35)37)85(75,76)77)19-39(25)56-47(58)27-5-3-7-31(17-27)52-51(62)53-32-8-4-6-28(18-32)48(59)57-40-20-30(12-10-26(40)2)50(61)55-38-14-16-42(84(72,73)74)36-22-34(82(66,67)68)24-44(46(36)38)86(78,79)80;;;;;;/h3-24H,1-2H3,(H,54,60)(H,55,61)(H,56,58)(H,57,59)(H2,52,53,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80);;;;;;/q;6*+1/p-6
InChI key
VAPNKLKDKUDFHK-UHFFFAOYSA-H
Gene Information
human ... EGF(1950), FGF1(2246), P2RX1(5023), P2RY1(5028), PDGFA(5154), PLD1(5337)
General description
Suramin is an antiparasitic drug, which blocks endothelial cell proliferation and increases tyrosine phosphorylation of many signalling proteins. It is associated with urticaria, paresthesias, vomiting and neurologic toxicity. Suramin is used to treat trypanosomiasis and onchocerciasis. It functions as an inhibitor of heparanase and also exhibits anti-AIDS (acquired immunodeficiency syndrome) property.
Application
Suramin sodium salt has been used:
- as a potent blocker of rat P2Y2 purinergic receptor
- to study its effects on short circuit current (Isc) across strial marginal cells
- to show its effects on initial burst of glial activity
- to assess its neuroprotective potential in rats
- as a purinoceptor inhibitor, to explore the mechanism of action of extracellular adenosine triphosphate (eATP)
Biochem/physiol Actions
Suramin is a polysulfonated naphthylurea anticancer agent that inhibits tumor cell proliferation. It inhibits the activity of topoisomerase II by blocking the binding of the enzyme to DNA. It′s antiangiogenic activity may be related to its ability to bind to and inhibit the activity of several growth factors, including FGFa, FGFb, and PGDF. It uncouples G-proteins from receptors. It is an broad spectrum antagonist at P2X and P2Y purinergic receptors. Suramin has well documented antiprotozoal and anthelmintic activity.
Other Notes
To gain a comprehensive understanding of our extensive range of Oligosaccharides for your research, we encourage you to visit our Carbohydrates Category page.
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This Item | |||
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥99% | assay ≥99.0% (HPLC) |
| solubility H2O: >10 mg/mL | solubility water: 5 mg/mL | solubility aqueous base: soluble | solubility H2O: 1 M at 20 °C, clear, colorless |
| Quality Level 200 | Quality Level 100 | Quality Level 200 | Quality Level 200 |
| form powder | form crystalline solid | form powder | form powder |
| impurities <15% water (Karl Fischer) | impurities - | impurities - | impurities DNases, none detected, RNases, none detected, insoluble matter, passes filter test, phosphatases, none detected, proteases, none detected |
| color white to light brown | color white | color - | color - |
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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S2671-100MGを購入しました。PBSで20 mg/ml のストックを作りたいのですが、溶解しますか？また最大限どれくらいまで溶解できますか？なお、溶解する時の注意点等があれば教えてください。
1 answer-
Helpful?
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How can I determine the shelf life / expiration / retest date of this product?
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If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdfHelpful?
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Is this the same suramin that is used for African sleeping sickness? If mixed with BAC water, can it be injected into humans?
1 answer-
This product is the same material as the drug used to treat African trypanosomiasis and onchocerciasis. However, this item is intended for research use only and not suitable for human or veterinary use.
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How is shipping temperature determined? And how is it related to the product storage temperature?
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Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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