S1076
SRC, active, GST tagged human
PRECISIO® Kinase, recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Synonym(s):
ASV, c-SRC, p60-Src
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About This Item
NACRES:
NA.32
UNSPSC Code:
12352200
Specific activity:
83-113 nmol/min·mg
Assay:
≥70% (SDS-PAGE)
Recombinant:
expressed in E. coli
Pricing and availability is not currently available.
General description
SRC proto-oncogene, non-receptor tyrosine kinase (SRC) belongs to the family of non-receptor tyrosine kinases. SRC was originally identified as a transforming protein of the Rous sarcoma virus (RSV) that had enzymatic ability to phosphorylate tyrosine in protein substrates. It contains an amino-terminal domain, conserved Src-homology domains (SH2 and SH3), a tyrosine kinase domain and the carboxyl-terminus. The gene encoding this protein is localized on human chromosome 20q11.23.
Application
SRC, active, GST tagged human has been used in the in vitro kinase assay.
Biochem/physiol Actions
SRC proto-oncogene, non-receptor tyrosine kinase (SRC) phosphorylates membrane proteins and nucleoproteins and activates various intracellular signaling cascades. It is overexpressed and activated in a large number of human malignancies and has been linked to the development of cancer and progression to distant metastases. In addition to increasing cell proliferation, a key role of SRC in cancer seems to be the ability to promote invasion and motility, functions that might contribute to tumor progression.
Physical form
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
Legal Information
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
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This Item | |||
|---|---|---|---|
| specific activity 83-113 nmol/min·mg | specific activity - | specific activity - | specific activity - |
| assay ≥70% (SDS-PAGE) | assay - | assay - | assay - |
| Gene Information human ... SRC(6714) | Gene Information human ... SRC(6714) | Gene Information human ... SRC(6714) | Gene Information human ... SRC(6714) |
| recombinant expressed in E. coli | recombinant - | recombinant - | recombinant - |
| form buffered aqueous glycerol solution | form buffered aqueous solution | form buffered aqueous solution | form buffered aqueous solution |
| shipped in dry ice | shipped in wet ice | shipped in wet ice | shipped in wet ice |
Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| S1076-10UG | 04061832851402 |