M2727

Mexiletine hydrochloride

≥98% (GC), powder, sodium channel blocker

• Synonym(s): 1-(2,6-Dimethylphenoxy)-2-propanamine hydrochloride, 1-(2,6-Xylyloxy)-2-aminopropane hydrochloride
• Empirical Formula (Hill Notation): C₁₁H₁₇NO · HCl
• CAS Number: 5370-01-4
• Molecular Weight: 215.72
• NACRES: NA.77
• PubChem Substance ID: 24278542
• UNSPSC Code: 12352200
• EC Number: 250-825-7
• MDL number: MFCD00216024
• Assay: ≥98% (GC)
• Form: powder

Properties

• Product Name: Mexiletine hydrochloride, powder
• assay: ≥98% (GC)
• Quality Segment: 200
• form: powder
• color: white to off-white
• solubility: methanol: 50 mg/mL
• originator: Boehringer Ingelheim
• storage temp.: 2-8°C
• SMILES string: Cl[H].CC(N)COc1c(C)cccc1C
• InChI: 1S/C11H17NO.ClH/c1-8-5-4-6-9(2)11(8)13-7-10(3)12;/h4-6,10H,7,12H2,1-3H3;1H
• InChI key: NFEIBWMZVIVJLQ-UHFFFAOYSA-N
• Gene Information: human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

Description

General description

Mexiletine is a class I B antiarrhythmic and an analog of lidocaine.[1] It has shelf life of 10-12 hours and is metabolized in liver and eliminated post reduction, oxidation deamination or conjugation.[2]

Application

Mexiletine hydrochloride has been used as a sodium channel blocker:

• expressed in chinese hamster ovary cells[3]
• in human embryonic kidney (HEK) cells for whole cell patch-clamp studies[4]
• electrophysiology studies in HEK cells expressing Nav1.7 protein[5]

Biochem/physiol Actions

Mexiletine is a potent sodium channel blocker. It is a cardiac antiarrhythmic and is used as an adjuvant in headache and neuropathic pain[1] Mexiletine is used for treating myotonia in sodium channelopathies[6] and reduces the cardiac action potential depolarization but shows no impact on atrial refractoriness. Its inhibitory effect on sodium channels is effective in treating potassium aggravated myotonia.[6]

Features and Benefits

This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable