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Dokumenty

916870

Sigma-Aldrich

4-(1-(tert-butoxycarbonyl)piperidin-4-yl)benzoic acid

≥95%

Synonim(y):

Semi-flexible linker for PROTAC® development

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About This Item

Wzór empiryczny (zapis Hilla):
C17H23NO4
Numer CAS:
149353-75-3
Masa cząsteczkowa:
305.37
Numer MDL:
MFCD02178897
Kod UNSPSC:
12352106

Poziom jakości

100

Próba

≥95%

Postać

powder

przydatność reakcji

reagent type: linker

grupa funkcyjna

Boc
carboxylic acid

temp. przechowywania

2-8°C

ciąg SMILES

O=C(N(CC1)CCC1C(C=C2)=CC=C2C(O)=O)OC(C)(C)C

InChI

1S/C17H23NO4/c1-17(2,3)22-16(21)18-10-8-13(9-11-18)12-4-6-14(7-5-12)15(19)20/h4-7,13H,8-11H2,1-3H3,(H,19,20)

Klucz InChI

YCNVQGGUCDVTIZ-UHFFFAOYSA-N

Zastosowanie

4-(1-(tert-Butoxycarbonyl)piperidin-4-yl)benzoic acid is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.

Inne uwagi

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Portal: Building PROTAC® Degraders for Targeted Protein Degradation

Informacje prawne

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
This page may contain text that has been machine translated.

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Piktogramy

Exclamation markEnvironment
GHS07,GHS09

Hasło ostrzegawcze

Warning

Zwroty wskazujące rodzaj zagrożenia

H315,H317,H319,H410

Zwroty wskazujące środki ostrożności

P261 - P264 - P273 - P280 - P302 + P352 - P305 + P351 + P338

Klasyfikacja zagrożeń

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Wybierz jedną z najnowszych wersji:

Certyfikaty analizy (CoA)

Lot/Batch Number
MKCV9412

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Andrei A Krysko et al.
Bioorganic & medicinal chemistry letters, 26(7), 1839-1843 (2016-02-26)
A series of 2-piperazin-1-yl-quinazolines were synthesized and evaluated for their antiaggregative activity. The synthesized small molecule compounds have potently inhibited platelet aggregation in vitro and blocked FITC-Fg binding to αIIbβ3 integrin in a suspension of washed human platelets. The key
Weilin Sun et al.
Journal of medicinal chemistry, 62(6), 3122-3134 (2019-03-16)
Imatinib mesylate, 1a, inhibits production of β-amyloid (Aβ) peptides both in cells and in animal models. It reduces both the β-secretase and γ-secretase cleavages of the amyloid precursor protein (APP) and mediates a synergistic effect, when combined with a β-secretase
Dominik K Kölmel et al.
ACS combinatorial science, 21(8), 588-597 (2019-07-10)
A new catalytic manifold that merges photoredox with nickel catalysis in aqueous solution is presented. Specifically, the combination of a highly active, yet air-stable, nickel precatalyst with a new electron-deficient pyridyl carboxamidine ligand was key to the development of a
Dillon T Flood et al.
Journal of the American Chemical Society, 141(25), 9998-10006 (2019-05-29)
DNA Encoded Libraries have proven immensely powerful tools for lead identification. The ability to screen billions of compounds at once has spurred increasing interest in DEL development and utilization. Although DEL provides access to libraries of unprecedented size and diversity
Andrei A Krysko et al.
Bioorganic & medicinal chemistry letters, 21(19), 5971-5974 (2011-08-20)
The novel RGD mimetics with phthalimidine central fragment were synthesized with the use of 4-piperidine-4-yl-butyric, 4-piperidine-4-yl-benzoic, 4-piperazine-4-yl-benzoic and 1,2,3,4-tetrahydroisoquinoline-7-carboxylic acids as surrogates of Arg motif. The synthesized compounds potently inhibited platelet aggregation in vitro and blocked FITC-Fg binding to α(IIb)β(3)

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