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916900

Sigma-Aldrich

2-(3-(Piperidin-4-yl)phenyl)ethan-1-ol hydrochloride

≥95%

Synonim(y):

Semi-flexible linker for PROTAC® development

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About This Item

Wzór empiryczny (zapis Hilla):
C13H20ClNO
Masa cząsteczkowa:
241.76
Kod UNSPSC:
12352116

Poziom jakości

100

Próba

≥95%

Postać

powder

przydatność reakcji

reagent type: linker

grupa funkcyjna

hydroxyl

temp. przechowywania

2-8°C

ciąg SMILES

OCCC1=CC(C2CCNCC2)=CC=C1.Cl

Zastosowanie

2-(3-(Piperidin-4-yl)phenyl)ethan-1-ol hydrochloride is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.

Inne uwagi

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Portal: Building PROTAC® Degraders for Targeted Protein Degradation

Informacje prawne

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

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Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

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