917907

2-(4-(Piperidin-4-yl)phenyl)ethan-1-amine dihydrochloride

≥95%

• Synonim(y): Semi-flexible linker for PROTAC^® development
• Wzór empiryczny (zapis Hilla): C₁₃H₂₂Cl₂N₂
• Masa cząsteczkowa: 277.23
• UNSPSC Code: 12352116
• Assay: ≥95%
• Form: powder

Właściwości

• Quality Segment: 100
• assay: ≥95%
• form: powder
• reaction suitability: reagent type: linker
• functional group: amine
• storage temp.: 2-8°C
• SMILES string: NCCC1=CC=C(C=C1)C2CCNCC2.Cl.Cl

Opis

Application

2-(4-(Piperidin-4-yl)phenyl)ethan-1-amine dihydrochloride is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.

Other Notes

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable