917850

tert-Butyl 4-(2-(2-hydroxyethyl)phenyl)piperidine-1-carboxylate

≥95%

• Synonim(y): Semi-flexible linker for PROTAC^® development
• Wzór empiryczny (zapis Hilla): C₁₈H₂₇NO₃
• Numer CAS: 170837-78-2
• Masa cząsteczkowa: 305.41
• UNSPSC Code: 12352116
• MDL number: MFCD30099263
• Assay: ≥95%
• Form: powder

Właściwości

• Quality Segment: 100
• assay: ≥95%
• form: powder
• reaction suitability: reagent type: linker
• functional group: Boc, hydroxyl
• storage temp.: 2-8°C
• SMILES string: O=C(N(CC1)CCC1C2=C(CCO)C=CC=C2)OC(C)(C)C

Opis

Application

tert-Butyl 4-(2-(2-hydroxyethyl)phenyl)piperidine-1-carboxylate is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.

Other Notes

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

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Informacja o środkach bezpieczeństwa

• pictograms: GHS07,GHS09
• signalword: Warning
• hcodes: H315,H317,H319,H410
• pcodes: P261 - P264 - P273 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1
• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable