917656

3-(Piperidin-4-yl)benzoic acid hydrochloride

≥95%

• Synonim(y): Semi-flexible linker for PROTAC^® development
• Wzór empiryczny (zapis Hilla): C₁₂H₁₆ClNO₂
• Numer CAS: 726185-55-3
• Masa cząsteczkowa: 241.71
• UNSPSC Code: 12352116
• MDL number: MFCD08460727
• Assay: ≥95%
• Form: powder

Właściwości

• Quality Segment: 100
• assay: ≥95%
• form: powder
• reaction suitability: reagent type: linker
• technique(s): targeted protein degradation: suitable
• functional group: carboxylic acid
• storage temp.: 2-8°C
• SMILES string: O=C(C1=CC(C2CCNCC2)=CC=C1)O.Cl

Opis

Application

3-(Piperidin-4-yl)benzoic acid hydrochloride is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.

Other Notes

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable