407952

Ionomycin, Calcium Salt, Streptomyces conglobatus

Ionomycin, Calcium Salt, Streptomyces conglobatus, CAS 56092-82-1, is useful in cell activation experiments when calcium dose-response data are not required.

• Synonim(y): Ionomycin, Calcium Salt, Streptomyces conglobatus
• Wzór empiryczny (zapis Hilla): C₄₁H₇₀O₉ · Ca
• Numer CAS: 56092-82-1
• Masa cząsteczkowa: 747.07
• UNSPSC Code: 12352200
• MDL number: MFCD00083634
• Assay: ≥97% (HPLC)
• Form: solid
• Quality level: 100
• Storage condition: OK to freeze, protect from light

Właściwości

• Quality Level: 100
• assay: ≥97% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: white to off-white
• solubility: DMSO: 100 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• InChI: 1S/C41H71O9.Ca/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42;/h11,13,24-33,36-37,39,42,45,48H,12,14-23H2,1-10H3,(H,46,47);/q-1;+2/p-1/b13-11+;/t25-,26-,27+,28-,29-,30+,31+,32-,33+,36+,37-,39-,40+,41+;/m1./s1
• InChI key: RULWQOBWZOQCOY-SQNLDGQHSA-M

Opis

General description

Highly specific for divalent cations (Ca²⁺ > Mg²⁺ >> Sr²⁺ = Ba²⁺) and more effective than antibiotic A23187 (Cat. No. 100105) as a mobile ion carrier for Ca²⁺. Complexes with Ca²⁺ between pH 7 and 9.5, with intense UV absorption. In contrast to A23187, it is not fluorescent. Useful for studies of Ca²⁺ transport across biological membranes. Induces apoptotic neuronal degeneration in embryonic cortical neurons. Also induces cell cycle arrest in the G₁ interval of mature Burkitt lymphoma cell lines. Often used in cell activation experiments when calcium dose-response data is not required.

Useful in cell activation experiments when calcium dose-response data are not required. Also available as a 10 mM solution in DMSO (Cat. No. 407953).

Biochem/physiol Actions

Cell permeable: no

Primary Target
Useful in cell activation experiments

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Other Notes

Dupuy d′Angeac, A., et al. 1993. J. Cell Physiol.154, 44.
Lee, H.C. 1993. J. Biol. Chem.268, 293.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

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Informacja o środkach bezpieczeństwa

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable