D2629

6-(Dimethylamino)purine

≥98%

• Synonim(y): 6-DMAP, N⁶,N⁶-Dimethyladenine
• Wzór empiryczny (zapis Hilla): C₇H₉N₅
• Numer CAS: 938-55-6
• Masa cząsteczkowa: 163.18
• Beilstein: 7634
• Numer WE: 213-344-3
• Numer MDL: MFCD00005573
• Kod UNSPSC: 41106305
• Identyfikator substancji w PubChem: 24893701
• NACRES: NA.51

Właściwości

• pochodzenie biologiczne: synthetic (organic)
• Próba: ≥98%
• Postać: powder
• mp: 259-262 °C (lit.)
• rozpuszczalność: water: 50 mg/mL, clear to hazy, colorless to light yellow
• temp. przechowywania: −20°C
• ciąg SMILES: CN(C)c1ncnc2[nH]cnc12
• InChI: 1S/C7H9N5/c1-12(2)7-5-6(9-3-8-5)10-4-11-7/h3-4H,1-2H3,(H,8,9,10,11)
• Klucz InChI: BVIAOQMSVZHOJM-UHFFFAOYSA-N

Opis

Opis ogólny

6-(Dimethylamino)purine (6-DMAP) is a purine-based metabolite with two condensed heterocyclic rings and two methyl groups linked to the amino group of the purine unit of adenine.

Zastosowanie

6-(Dimethylamino)purine has been used:

• as a supplement in GR-1 aa medium (bovine medium) for parthenogenetic activation of bovine oocytes to study its potential for embryo development
• in the activation step during the production of nuclear transfer embryos
• as a supplement in HCR2aa medium to activate interspecies embryos derived from interspecies somatic cell nuclear transfer (iSCNT) technique

Działania biochem./fizjol.

6-(Dimethylamino)purine (6-DMAP) is a protein kinase and cyclin-dependent kinase inhibitor. It acts as a secondary metabolite and mediates RNA modification. 6-DMAP is a potent cytokinetic inhibitor and is used in parthenogenesis and meiosis studies. It is also used to promote pronuclei formation in mammalian oocytes. 6-DMAP is a dual fluorescence molecule according to femtosecond fluorescence up-conversion spectroscopy studies.

Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)