The reconstitution guidelines for item B7651, Brefeldin A, are as follows: it is soluble in water (partly miscible), methanol (10 mg/mL), ethanol (5 mg/mL), DMSO (20 mg/mL), acetone, and ethyl acetate (1 mg/mL).
Przejdź do
B7651
Brefeldin A
from Penicillium brefeldianum, ≥99% (HPLC and TLC), powder, activator of the sphingomyelin cycle
Synonim(y):
Nectrolide, γ,4-Dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic acid λ-lactone, Ascotoxin, BFA, Cyanein, Decumbin
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Zmień widok
| Do Państwa/SKU | Dostępność | Cena netto |
|---|---|---|
5 mg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 798,00 zł |
25 mg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 3420,00 zł |
Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C16H24O4
Numer CAS:
Masa cząsteczkowa:
280.36
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Beilstein/REAXYS Number:
25191
Assay:
≥99% (HPLC and TLC)
Form:
powder
798,00 zł
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
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Pozwól nam pomócNazwa produktu
Brefeldin A, from Penicillium brefeldianum, ≥99% (HPLC and TLC)
biological source
Penicillium brefeldianum
Quality Segment
assay
≥99% (HPLC and TLC)
form
powder
solubility
DMSO: 10 mg/mL
antibiotic activity spectrum
neoplastics
mode of action
protein synthesis | interferes
storage temp.
2-8°C
SMILES string
C[C@H]1CCC\C=C\[C@@H]2C[C@H](O)C[C@H]2[C@H](O)\C=C\C(=O)O1
InChI
1S/C16H24O4/c1-11-5-3-2-4-6-12-9-13(17)10-14(12)15(18)7-8-16(19)20-11/h4,6-8,11-15,17-18H,2-3,5,9-10H2,1H3/b6-4+,8-7+/t11-,12+,13-,14+,15+/m0/s1
InChI key
KQNZDYYTLMIZCT-KQPMLPITSA-N
General description
Brefeldin A (BFA) is a fungal metabolite containing a 13-membered macrocyclic lactone ring. [1] It inhibits protein and nucleic acid synthesis. BFA blocks the exchange of GDP for GTP on adenosine ribosylation factors (ARFs), thereby hindering the binding of coat protein (β-COP) and consequently disrupts the structure and function of the Golgi apparatus. BFA is an activator of the sphingomyelin cycle. Brefeldin A-mediated apoptosis has been observed in human tumor cells. Brefeldin A has been shown to increase CRISPR-mediated homology-directed repair (HDR) efficiency. It demonstrates a diverse array of biological functions, including antitumor, antiviral, antibiotic, antimitotic, antifungal and antinematodal properties.
Application
Biochem/physiol Actions
Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus. BFA is an activator of the sphingomyelin cycle. Brefeldin A-mediated apoptosis has been observed in human tumor cells.
Brefeldin A has been shown to increase CRISPR-mediated homology-directed repair (HDR) efficiency.
Disrupts the structure and function of the Golgi apparatus; activator of the sphingomyelin cycle.
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Ta pozycja | |||
|---|---|---|---|
| form powder | form powder | form ready-to-use solution | form powder |
| assay ≥99% (HPLC and TLC) | assay ≥99% (HPLC and TLC) | assay - | assay ≥98% (HPLC) |
| Quality Level 300 | Quality Level 300 | Quality Level 200 | Quality Level 200 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C |
| solubility DMSO: 10 mg/mL | solubility DMSO: 10 mg/mL (Store stock solutions at -20 °C) | solubility DMSO: 10 mg/mL | solubility DMSO: 1 mg/mL, methanol: 1 mg/mL |
| antibiotic activity spectrum neoplastics | antibiotic activity spectrum neoplastics | antibiotic activity spectrum neoplastics | antibiotic activity spectrum viruses |
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signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral
Klasa składowania
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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How should item B7651, Brefeldin A, be reconstituted?
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