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Merck

I9657

Ionomycin from Streptomyces conglobatus

≥98% (HPLC)

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1 MG

1600,00 zł

5 MG

6720,00 zł

1600,00 zł

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Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):
C41H72O9
Numer CAS:
56092-81-0
Masa cząsteczkowa:
709.00
UNSPSC Code:
51102829
NACRES:
NA.85
PubChem Substance ID:
24896159
MDL number:
MFCD06798385
Beilstein/REAXYS Number:
3642126

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SMILES string

C[C@H](CCC(O)=O)C[C@H](C)C[C@H](C)C(=O)\C=C(/O)[C@H](C)C[C@H](C)C\C=C\[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)C[C@@H]1CC[C@](C)(O1)[C@H]2CC[C@](C)(O2)[C@@H](C)O

InChI key

PGHMRUGBZOYCAA-ADZNBVRBSA-N

InChI

1S/C41H72O9/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42/h11,13,24-33,36-37,39,42-43,45,48H,12,14-23H2,1-10H3,(H,46,47)/b13-11+,34-24-/t25-,26-,27+,28-,29-,30+,31+,32-,33+,36+,37-,39-,40+,41+/m1/s1

biological source

Streptomyces conglobatus

assay

≥98% (HPLC)

solubility

acetonitrile: 10 mg/mL

antibiotic activity spectrum

Gram-positive bacteria

mode of action

cell membrane | interferes

storage temp.

−20°C

Quality Level

300

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Ta pozycja
I3909I0634M7949
Ionomycin from Streptomyces conglobatus ≥98% (HPLC)

Sigma-Aldrich

I9657

Ionomycin from Streptomyces conglobatus

Ionomycin calcium salt Ready Made Solution, from Streptomyces conglobatus, 1 mM in DMSO

Sigma-Aldrich

I3909

Ionomycin calcium salt

Ionomycin calcium salt from Streptomyces conglobatus powder, ≥98% (HPLC)

Sigma-Aldrich

I0634

Ionomycin calcium salt from Streptomyces conglobatus

Mitomycin C from Streptomyces caespitosus ≥98% (HPLC), γ-irradiated, suitable for cell culture

Sigma-Aldrich

M7949

Mitomycin C from Streptomyces caespitosus

mode of action

cell membrane | interferes

mode of action

cell membrane | interferes

mode of action

cell membrane | interferes

mode of action

DNA synthesis | interferes

antibiotic activity spectrum

Gram-positive bacteria

antibiotic activity spectrum

Gram-positive bacteria

antibiotic activity spectrum

Gram-positive bacteria

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, neoplastics

Quality Level

300

Quality Level

300

Quality Level

300

Quality Level

200

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

biological source

Streptomyces conglobatus

biological source

Streptomyces conglobatus

biological source

-

biological source

Streptomyces caespitosus

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

Application

Ionomycin from Streptomyces conglobatus has been used:
  • in magnesium-ionomycin treatment experiments
  • as a supplement in calcium-free Dulbecco′s modified Eagle medium (DMEM) for ionophore treatment
  • in the restimulation of peripheral blood mononuclear cells (PBMCs) to analyze cytokine production using flow cytometry (FCM)
  • as a calcium ionophore to treat oocytes to perform intracytoplasmic sperm injection (ICSI) combined with assisted oocyte activation (AOA)

Biochem/physiol Actions

Ionomycin is a polyether antibiotic and an ionophore produced by the bacterium Streptomyces conglobatus. This Ca2+ ionophore is more effective than A23187 as a mobile ion carrier for Ca2+. It is non-fluorescent. It induces apoptotic degeneration of embryonic cortical neurons. Ionomycin has been shown to induce central demyelination, inhibit adrenal bovine TREK-1 channels, and regulate cell division of mature human B cells. It is used to study the effects of calcium flux on endoplasmic reticulum (ER) stress, mitochondrial stress, and intrinsic apoptosis mechanisms. It also stimulates the intracellular production of cytokines, interferon, perforin, interleukin-2 (IL-2), and IL-4 usually in conjunction with PMA.
Ionomycin is highly specific for divalent cations. It may have antiproliferative effects on the human bladder cancer cell line both in vitro and in vivo. Ionomycin functions as an apoptosis inducer which was suggested to act by activation of a latent, calcium-responsive endonuclease.
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ppe

dust mask type N95 (US), Eyeshields, Gloves

Klasa składowania

10 - Combustible liquids

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Certyfikaty analizy (CoA)

Lot/Batch Number
0000528803
0000528803
0000436786
0000436786
0000368954

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Odwiedź Bibliotekę dokumentów

Lauren M Sparks et al.
PloS one, 6(7), e21068-e21068 (2011-07-16)
Disturbances in lipid metabolism are strongly associated with insulin resistance and type 2 diabetes (T2D). We hypothesized that activation of cAMP/PKA and calcium signaling pathways in cultured human myotubes would provide further insight into regulation of lipid storage, lipolysis, lipid
Davina Bonte et al.
Fertility and sterility, 112(2), 266-274 (2019-05-28)
To investigate the extent to which assisted oocyte activation (AOA) improves clinical outcomes in patients diagnosed with oocyte activation deficiencies (OADs). Retrospective cohort study comparing AOA cycles and previous intracytoplasmic sperm injection (ICSI) cycles in couples experiencing low or total
Pierre Gantner et al.
Nature communications, 11(1), 4089-4089 (2020-08-17)
Clonal expansions occur in the persistent HIV reservoir as shown by the duplication of proviral integration sites. However, the source of the proliferation of HIV-infected cells remains unclear. Here, we analyze the TCR repertoire of single HIV-infected cells harboring translation-competent
Julia Niessl et al.
EBioMedicine, 54, 102727-102727 (2020-04-09)
Untreated HIV infection leads to alterations in HIV-specific CD4+ T cells including increased expression of co-inhibitory receptors (IRs) and skewing toward a T follicular helper cell (Tfh) signature. However, which changes are maintained after suppression of viral replication with antiretroviral
Ye Tian et al.
BMC women's health, 20(1), 246-246 (2020-11-06)
Fertilization failure after intracytoplasmic sperm injection continues to affect couples and the etiology is not well-understood. We characterized a couple with 2-year history of primary unexplained infertility. Three different assisted reproduction attempts (IVF + rescue ICSI, ICSI and ICSI-AOA) showed repeated fertilization
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Questions

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  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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