This product is not assigned an expiration or retest date. Products that are not assigned expiration or retest dates are quite stable and are warranteed for 1 year from the date of shipment. Following reconstitution, stock solutions may be stored for up to 3 months at -20°C in working aliquots. Avoid repeated freeze/thaw cycles. Please see the link below to review additional information available in the complete Product Dating Statement:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/190/408/product-dating-information-ms.pdf?.
L7635
L-α-Lysophosphatidylinositol sodium salt from Glycine max (soybean)
≥96%
Sinónimos:
1-Acyl-sn-glycero-3-phospho-(1-D-myo-inositol)
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Servicio técnico
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Permítanos ayudarlebiological source
soybean
Quality Level
assay
≥96%
form
powder
functional group
phospholipid
lipid type
phosphoglycerides
shipped in
ambient
storage temp.
−20°C
Application
L-α-Lysophosphatidylinositol sodium salt from Glycine max (soybean) has been used as an agonist of G protein-coupled receptor 55 (GPR55).
Biochem/physiol Actions
L-α-Lysophosphatidylinositols (LPI) functions as an endogenous ligand for putative cannabinoid receptor and G protein-coupled receptor 55 (GPR55). LPI plays a regulatory role in cell proliferation, migration and function. Increased circulatory levels of LPI has been observed in the obese patients. In addition, overexpression of LPI leads to the development of various types of cancers including ovarian and breast cancer. LPI can be used as a potential diagnostic and prognostic biomarker for ovarian cancer.
L-α-Lysophosphatidylinositols from Glycine max (soybean) are enriched with stearate and palmitate. Soybean Lysophosphatidylinositols may be compared with other lysophosphatidylinositol for biological activities which depend upon the identity of the acylated fatty acid.
Preparation Note
Prepared by the action of phospholipase A on L-α-phosphatidylinositol.
Analysis Note
Contains primarily palmitic and stearic acids.
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Este artículo | |||
|---|---|---|---|
| assay ≥96% | assay ≥99% | assay ≥98.0% (TLC) | assay - |
| functional group phospholipid | functional group phospholipid | functional group phospholipid | functional group phospholipid |
| biological source soybean | biological source soybean | biological source soybean | biological source soybean |
| form powder | form powder | form powder | form crude powder |
| shipped in ambient | shipped in ambient | shipped in ambient | shipped in ambient |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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A role for L-alpha-lysophosphatidylinositol and GPR55 in the modulation of migration, orientation and polarization of human breast cancer cells
Ford LA, et al.
British Journal of Pharmacology, 160(3), 762-771 (2010)
Lysophosphatidylinositol signalling: New wine from an old bottle.
Pi?eiro R, Falasca M.
Biochimica et Biophysica Acta, 182, 694-705 (2012)
A novel biological role for the phospholipid lysophosphatidylinositol in nociceptive sensitization via activation of diverse G-protein signaling pathways in sensory nerves in vivo
Gangadharan V, et al.
Pain, 154(12) (2013)
Número de artículo de comercio global
| SKU | GTIN |
|---|---|
| L7635-5MG | 04061832795898 |
| L7635-1MG | 04061833965603 |
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Wie lang ist LPI bei -20°C haltbar?
1 answer-
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What fatty acid groups does L-α-Lysophosphatidylinositol sodium salt from Glycine max, Product L7635, contain?
1 answer-
The main fatty acid group is palmitic acid. The next most abundant fatty acid groups tend to be stearic acid and linolenic acid, and then oleic acid and linoleic acid.
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What is the molecular weight of L-α-Lysophosphatidylinositol sodium salt from Glycine max, Product L7635?
1 answer-
We have calculated a value of 605.1, based on the structure of phosphatidyl-1-inositol and the assumption that the main fatty acids present as part of the structure are C16:0 (58%) and C18:0 and C18:2 (42%).
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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