A6719

ω-Agatoxin IVA

≥90% (HPLC)

• Synonym(s): SNX 290
• Empirical Formula (Hill Notation): C₂₁₇H₃₆₀N₆₈O₆₀S₁₀
• CAS Number: 145017-83-0
• Molecular Weight: 5202.25
• UNSPSC Code: 12352200
• NACRES: NA.28
• MDL number: MFCD00165055

Properties

• Quality Segment: 200
• assay: ≥90% (HPLC)
• form: powder
• application(s): metabolomics; vitamins, nutraceuticals, and natural products
• storage temp.: −20°C
• Gene Information: human ... CACNA1A(773) ; mouse ... CACNA1A(12286) ; rat ... CACNA1A(25398)

Description

General description

CACNA1A (calcium voltage-gated channel subunit alpha1 A) gene codes for the α1 subunit of neuronal CaV2.1 (P/Q-type) voltage-gated calcium channels. It is expressed throughout the central nervous system (CNS). CACNA1A gene is located on human chromosome 19p13.

Application

ω-Agatoxin IVA has been used in the manipulation of calcium influx. It has also been used in the study to characterize the spontaneous and evoked activity from murine ventral horn cultures on microelectrode arrays.[1]

Biochem/physiol Actions

Toxin found in the venom of the funnel web spider, Agelenopsis aptera. Potent, selective blocker of mammalian P-type voltage-dependent calcium channels.

Mutations in the CACNA1A (calcium voltage-gated channel subunit alpha1 A) gene is responsible for episodic ataxia 2, familial hemiplegic migraine type 1 (FHM1) and spinocerebellar ataxia type 6 (SCA6).

Features and Benefits

This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable