V7264

Venlafaxine hydrochloride

≥98% (HPLC), serotonin-noradrenaline reuptake inhibitor, powder

• Synonym(s): (+/-)-1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol hydrochloride, Effexor
• Empirical Formula (Hill Notation): C₁₇H₂₇NO₂ · HCl
• CAS Number: 99300-78-4
• Molecular Weight: 313.86
• UNSPSC Code: 12352200
• PubChem Substance ID: 329829062
• NACRES: NA.77
• MDL number: MFCD03658865
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated, protect from light

Properties

• Product Name: Venlafaxine hydrochloride, ≥98% (HPLC), powder
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated, protect from light
• color: white
• solubility: H₂O: >10 mg/mL
• originator: Wyeth
• SMILES string: Cl[H].COc1ccc(cc1)C(CN(C)C)C2(O)CCCCC2
• InChI: 1S/C17H27NO2.ClH/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14;/h7-10,16,19H,4-6,11-13H2,1-3H3;1H
• InChI key: QYRYFNHXARDNFZ-UHFFFAOYSA-N
• Gene Information: human ... SLC6A2(6530), SLC6A4(6532)

Description

Biochem/physiol Actions

Venlafaxine is a dual serotonin-noradrenaline reuptake inhibitor that displays Ki values of 82 and 2480 nM respectively. It is a general class antidepressant.

Venlafaxine is an antidepressant. The mechanism of the antidepresant action of venlafaxine in humans is associated with its potentiation of neurotransmitter activity in the CNS. Venlafaxine is a potent inhibitor of neuronal serotonin and norepinephrine reuptake and weak inhibitor of dopamine reuptake. Venlafaxine has no significant activity for muscarinic, histaminergic, or α-1 adrenergic receptors in vitro. Venlafaxine does not possess MAO inhibitor activity.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• pictograms: GHS09
• hcodes: H411
• pcodes: P273 - P391 - P501
• Hazard Classifications: Aquatic Chronic 2
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves