If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf
T7883
Trimethoprim
≥98.5%
Synonym(s):
2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine, NSC 106568
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| Pack Size | SKU | Availability | Price |
|---|
About This Item
Quality Segment
assay
≥98.5%
form
powder
storage condition
(Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)
color
white to light yellow
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria, mycobacteria
mode of action
DNA synthesis | interferes, enzyme | inhibits
storage temp.
2-8°C
SMILES string
COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC
InChI
1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)
InChI key
IEDVJHCEMCRBQM-UHFFFAOYSA-N
Gene Information
human ... DHFRP1(573971), KCNH1(3756)
rat ... Dhfr(24312)
General description
Application
Biochem/physiol Actions
Packaging
Other Notes
1 of 1
This Item | |||
|---|---|---|---|
| mode of action DNA synthesis | interferes, enzyme | inhibits | mode of action DNA synthesis | interferes, enzyme | inhibits | mode of action DNA synthesis | interferes, enzyme | inhibits | mode of action - |
| antibiotic activity spectrum Gram-negative bacteria, mycobacteria, Gram-positive bacteria | antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria, mycobacteria | antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria, mycoplasma | antibiotic activity spectrum - |
| Quality Level 200 | Quality Level 200 | Quality Level 100 | Quality Level 300 |
| form powder | form powder | form - | form - |
| assay ≥98.5% | assay ≥99.0% (HPLC) | assay - | assay - |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Repr. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| T7883-100G | 04061837378706 |
| T7883-5G | 04061835550319 |
| T7883-25G | 04061835514304 |
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How can I determine the shelf life / expiration / retest date of this product?
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How is shipping temperature determined? And how is it related to the product storage temperature?
1 answer-
Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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Is it soluable in water or dmso and at what concentration should I use it?
1 answer-
This material is practically insoluble in water at 0.4 mg/mL Additional solvents include the following:
DMSO at 50 mg/mL
methanol at 12 mg/mL
chloroform at 18 mg/mL
propyleneglycol at 25 mg/mL
benzyl alcohol at 72 mg/mL
dimethylacetamide at 138 mg/mLHelpful?
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Is Trimethoprim stable in solution?
1 answer-
Triemethoprim in a solution of 52% N,N dimethylacetamide:48% propylene glycol at 50 mg/ml is stable when stored at 25° C. There is only a 10% degradation of trimethoprim under these conditions after 885 days.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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