I2512

Sodium iodoacetate

powder, ≥98%

• Synonym(s): Iodoacetic acid sodium salt
• Linear Formula: ICH₂COONa
• CAS Number: 305-53-3
• Molecular Weight: 207.93
• NACRES: NA.77
• PubChem Substance ID: 24895977
• UNSPSC Code: 12352202
• EC Number: 206-165-7
• MDL number: MFCD00002686
• Beilstein/REAXYS Number: 4009322

Properties

• Product Name: Sodium iodoacetate, ≥98%
• biological source: synthetic (organic)
• Quality Segment: 200
• assay: ≥98%
• form: powder
• mp: 208 °C (dec.) (lit.)
• solubility: H₂O: 100 mg/mL
• storage temp.: −20°C
• SMILES string: [Na+].[O-]C(=O)CI
• InChI: 1S/C2H3IO2.Na/c3-1-2(4)5;/h1H2,(H,4,5);/q;+1/p-1
• InChI key: AGDSCTQQXMDDCV-UHFFFAOYSA-M

Description

Application

Reagent for the modification of cysteine residues in proteins.

Reagent for the modification of cysteine residues in proteins. Used in protein sequencing (including by Sanger in sequencing bovine insulin) to prevent oxidation of -SH sidechains.

Reagent for the modification of cysteine residues in proteins. Used to induce animal osteoarthritis model system, which mimics both symptoms and histopathology of the human disease.

Biochem/physiol Actions

Used to induce osteoarthritis-like lesions and functional impairment in rats, for testing of chondroprotective agents and diagnostic imaging techniques.[1]

Safety Information

• pictograms: GHS06,GHS05
• signalword: Danger
• hcodes: H301,H314
• pcodes: P260 - P270 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Eye Dam. 1 - Skin Corr. 1B
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk: WGK 3
• flash_point_f: 406.4 °F
• flash_point_c: 208 °C
• ppe: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges