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Perphenazine

Name: Perphenazine
Brand: SIGMA

Synonym(s):

4-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-1-piperazineethanol

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About This Item

Empirical Formula (Hill Notation):

C₂₁H₂₆ClN₃OS

CAS Number:

58-39-9

Molecular Weight:

403.97

NACRES:

NA.77

PubChem Substance ID:

24278642

UNSPSC Code:

12352200

EC Number:

200-381-5

MDL number:

MFCD00056798

Form:

powder

Quality level:

200

Pricing and availability is not currently available.

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Properties

form

powder

Quality Level

200

originator

Schering Plough

storage temp.

2-8°C

SMILES string

ClC(C=C1)=CC2=C1SC3=CC=CC=C3N2CCCN4CCN(CCO)CC4

InChI

1S/C21H26ClN3OS/c22-17-6-7-21-19(16-17)25(18-4-1-2-5-20(18)27-21)9-3-8-23-10-12-24(13-11-23)14-15-26/h1-2,4-7,16,26H,3,8-15H2

InChI key

RGCVKNLCSQQDEP-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152), DRD2(1813), OPRS1(10280)

Description

General description

Perphenazine is an antipsychotic drug used in treating schizophrenia. It modulates antioxidant levels and helps in the management of oxidative injury in schizophrenia. However, it is less effective than the clozapine drug group in improving response to oxidative injury.

Biochem/physiol Actions

D₂ dopamine receptor antagonist; α-adrenergic receptor antagonist and σ-receptor agonist; phenothiazine antipsychotic. Inhibits glutamate dehydrogenase in vitro.

Features and Benefits

This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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This Item	P0550000	BP422	1511000
Sigma-Aldrich P6402 Perphenazine	P0550000 Perphenazine	BP422 Perphenazine	USP 1511000 Perphenazine
form powder	form -	form solid	form -
Quality Level 200	Quality Level -	Quality Level -	Quality Level -
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. -
originator Schering Plough	originator -	originator -	originator -
Gene Information human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152), DRD2(1813), OPRS1(10280)	Gene Information human ... DRD2(1813)	Gene Information human ... DRD2(1813)	Gene Information human ... DRD2(1813)

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pictograms

GHS07

signalword

Warning

hcodes

H302,H317

pcodes

P261 - P264 - P272 - P280 - P301 + P312 - P302 + P352

Hazard Classifications

Acute Tox. 4 Oral - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

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Impact of second-generation antipsychotics and perphenazine on depressive symptoms in a randomized trial of treatment for chronic schizophrenia.

Donald E Addington et al.

The Journal of clinical psychiatry, 72(1), 75-80 (2010-09-28)

According to the American Psychiatric Association Clinical Practice Guidelines for schizophrenia, second-generation antipsychotics may be specifically indicated for the treatment of depression in schizophrenia. We examined the impact of these medications on symptoms of depression using the data from the

Impact of the CATIE trial on antipsychotic prescribing patterns at a state psychiatric facility.

Angela M Koranek et al.

Schizophrenia research, 137(1-3), 137-140 (2012-03-01)

Results from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) indicate that, with the exception of olanzapine, no substantial overall differences were identified between second generation antipsychotics (SGAs) and the first generation antipsychotic (FGA) perphenazine. This study evaluated the effect

Effects of psychotropic drugs on cell proliferation and differentiation.

J Nordenberg et al.

Biochemical pharmacology, 58(8), 1229-1236 (1999-09-16)

Some of the psychotropic agents widely used for the amelioration of anxiety, depression, and psychosis also show an effect at the cellular proliferation level. Surprisingly little research, however, has been directed to the antitumoral potential of these drugs, alone or

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Global Trade Item Number

SKU	GTIN
P6402-5G	04061832092775
P6402-1G	04061834393320