F7807
Prostaglandin F Synthase human
recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
Synonym(s):
17-beta-hydroxysteroid dehydrogenase type 5, AKR1C3, aldo-keto reductase family 1 member C3, indanol dehydrogenase
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About This Item
CAS Number:
MDL number:
UNSPSC Code:
12352204
NACRES:
NA.54
Specific activity:
≥0.4 μmol/mg protein
Assay:
≥90% (SDS-PAGE)
Recombinant:
expressed in E. coli
Pricing and availability is not currently available.
recombinant
expressed in E. coli
Quality Level
description
contains a C-terminal hexahistidine tag
assay
≥90% (SDS-PAGE)
form
liquid
specific activity
≥0.4 μmol/mg protein
mol wt
~37 kDa
NCBI accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... AKR1C3(8644)
Application
Prostaglandin F synthase (PGF synthase) is a member of the aldo-keto reductase superfamily of proteins which catalyze the conversion of aldehydes and ketones to thier corresponding alcohols. Prostaglandin F synthase is used in cancer research since it is upregulated in many cancers such as breast and prostate cancer. PGF synthase is also used to study kidney and renal cell carcinoma [1].
Biochem/physiol Actions
PGF synthase catalyzes the conversions of 4-androstene-3,17-dione to testosterone, estrone to 17β-estradiol, prostaglandin H2 to PGF2α, and PGD2 to 9α,11β-PGF2. Prostaglandin (PG) F2 is synthesized via three pathways [2].
Other Notes
One unit is defined as the amount of enzyme required to produce 1 μmol of NADP per minute at 37°C in 50 mM KPO4 pH 7.2 containing 250 μM NADPH and 25 μM 9,10-phenanthrenequinone
1 of 1
This Item | |||
|---|---|---|---|
| Gene Information human ... AKR1C3(8644) | Gene Information human ... ALDH2(217) | Gene Information human ... AKR1D1(6718) | Gene Information - |
| assay ≥90% (SDS-PAGE) | assay ≥90% (SDS-PAGE) | assay - | assay ≥94% (HPLC) |
| specific activity ≥0.4 μmol/mg protein | specific activity - | specific activity - | specific activity - |
| recombinant expressed in E. coli | recombinant expressed in E. coli | recombinant - | recombinant - |
| form liquid | form liquid | form buffered aqueous solution | form solid |
| storage temp. −70°C | storage temp. −70°C | storage temp. −20°C | storage temp. 2-8°C |
Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Trevor M Penning et al.
Annals of the New York Academy of Sciences, 1155, 33-42 (2009-03-03)
Prostate and breast cancer are hormone-dependent malignancies of the aging male and female and require the local production of androgens and estrogens to stimulate cell proliferation. Aldo-keto reductases (AKR) play key roles in this process. In the prostate, AKR1C3 (type
Michal H Wrobel et al.
Toxicology, 262(3), 224-229 (2009-06-25)
Polychlorinated biphenyls (PCBs) stimulate in vitro both the force of myometrial contractions and endometrial secretion of PGF2alpha in cattle. Therefore, the goal of this study was to investigate the participation of PGF2alpha in the effect of PCBs on uterine contractility.
Agnieszka Waclawik et al.
Reproduction (Cambridge, England), 140(4), 613-622 (2010-07-10)
Oxytocin (OXT) and tumor necrosis factor α (TNF) have been implicated in the control of luteolysis by stimulating endometrial secretion of luteolytic prostaglandin F(2α) (PGF(2α)). Nevertheless, OXT concentration in porcine uterine lumen increases markedly on days 11-12 of pregnancy, and
Global Trade Item Number
| SKU | GTIN |
|---|---|
| F7807-50UG | 04061832729527 |