Key Documents

Medroxyprogesterone 17-acetate

Name: Medroxyprogesterone 17-acetate
Brand: SIGMA

synthetic (organic), ≥97% (HPLC), synthetic progestogen, powder

Synonym(s):

17α-Acetoxy-6α-methylprogesterone, 17α-Hydroxy-6α-methyl-4-pregnene-3,20-dione 17-acetate, 6α-Methyl-17α-acetoxyprogesterone, 6α-Methyl-17α-hydroxyprogesterone acetate

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About This Item

Empirical Formula (Hill Notation):

C₂₄H₃₄O₄

CAS Number:

71-58-9

Molecular Weight:

386.52

NACRES:

NA.77

PubChem Substance ID:

24896674

UNSPSC Code:

12352200

EC Number:

200-757-9

MDL number:

MFCD00010483

Beilstein/REAXYS Number:

2066112

Assay:

≥97% (HPLC)

Form:

powder

Quality level:

100

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Properties

Product Name

Medroxyprogesterone 17-acetate, ≥97% (HPLC)

biological source

synthetic (organic)

Quality Level

100

sterility

non-sterile

assay

≥97% (HPLC)

form

powder

mp

206-207 °C (lit.)

solubility

chloroform: 350 mg/mL, clear, colorless

shipped in

ambient

storage temp.

room temp

SMILES string

[H][C@@]12C[C@H](C)C3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@@]4(C)[C@@]2([H])CC[C@]4(OC(C)=O)C(C)=O

InChI

1S/C24H34O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h13-14,18-20H,6-12H2,1-5H3/t14-,18+,19-,20-,22+,23-,24-/m0/s1

InChI key

PSGAAPLEWMOORI-PEINSRQWSA-N

Gene Information

human ... AR(367), ESR1(2099), ESRRA(2101), NR3C1(2908), NR3C2(4306), PGR(5241)
rat ... Ar(24208)

Description

Biochem/physiol Actions

Medroxyprogesterone 17-acetate (MPA) is a synthetic progestin used as a contraceptive, in hormone replacement therapy and for the treatment of endometriosis. It is a more potent progestin that the nonacetylated form.

Features and Benefits

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item	BP221	PHR1589	Y0001484
Sigma-Aldrich M1629 Medroxyprogesterone 17-acetate	BP221 Medroxyprogesterone acetate	Supelco PHR1589 Medroxyprogesterone Acetate	Y0001484 Medroxyprogesterone acetate for peak identification
form powder	form solid	form -	form -
assay ≥97% (HPLC)	assay -	assay -	assay -
Quality Level 100	Quality Level -	Quality Level 300	Quality Level -
storage temp. room temp	storage temp. -	storage temp. 2-30°C	storage temp. 2-8°C
solubility chloroform: 350 mg/mL, clear, colorless	solubility -	solubility -	solubility -
shipped in ambient	shipped in -	shipped in -	shipped in -

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pictograms

GHS08

signalword

Warning

hcodes

H351,H413

pcodes

P202 - P273 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Aquatic Chronic 4 - Carc. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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An effective anti-human immunodeficiency virus-1 (HIV-1) microbicide should exert its action in the absence of causing aberrant activation of topical immunity that will increase the risk of HIV acquisition. In the present study, we demonstrated that the vaginal application of

Progestins Upregulate FKBP51 Expression in Human Endometrial Stromal Cells to Induce Functional Progesterone and Glucocorticoid Withdrawal: Implications for Contraceptive- Associated Abnormal Uterine Bleeding.

Ozlem Guzeloglu Kayisli et al.

PloS one, 10(10), e0137855-e0137855 (2015-10-06)

Use of long-acting progestin only contraceptives (LAPCs) offers a discrete and highly effective family planning method. Abnormal uterine bleeding (AUB) is the major side effect of, and cause for, discontinuation of LAPCs. The endometria of LAPC-treated women display abnormally enlarged

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Global Trade Item Number

SKU	GTIN
M1629-1G	04061838342478
M1629-10G	04061834040965

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