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B7283

Benserazide hydrochloride

≥98% (HPLC), solid, L-aromatic amino acid decarboxylase inhibitor

Synonym(s):

DL-Serine 2-(2,3,4-trihydroxybenzyl)hydrazide hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C10H15N3O5 · HCl
CAS Number:
14919-77-8
Molecular Weight:
293.70
NACRES:
NA.77
PubChem Substance ID:
24277886
UNSPSC Code:
12352125
EC Number:
238-991-9
MDL number:
MFCD00078571
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100
Pricing and availability is not currently available.
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Product Name

Benserazide hydrochloride, ≥98% (HPLC), solid

biological source

synthetic

Quality Level

100

assay

≥98% (HPLC)

form

solid

solubility

H2O: 10 mg/mL

originator

Roche

storage temp.

room temp

SMILES string

Cl.NC(CO)C(=O)NNCc1ccc(O)c(O)c1O

InChI

1S/C10H15N3O5.ClH/c11-6(4-14)10(18)13-12-3-5-1-2-7(15)9(17)8(5)16;/h1-2,6,12,14-17H,3-4,11H2,(H,13,18);1H

InChI key

ULFCBIUXQQYDEI-UHFFFAOYSA-N

Gene Information

human ... DDC(1644)

General description

Benserazide is a peripheral decarboxylase inhibitor.

Application

Benserazide has been used:
  • to inhibit dopa-decarboxylase
  • to induce dyskinesia
  • to test on purified bacterial TDCs to assess the extent to which it could affect bacterial decarboxylases
  • as a peripheral dopa decarboxylase inhibitor to treat mice

Biochem/physiol Actions

Inhibitor of L-aromatic amino acid decarboxylase.
Benserazide can block HK2 enzymatic activity in vitro. It is used along with levodopa to treat Parkinson′s disease.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

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This Item
B0477000Y0002115BP685
Benserazide hydrochloride ≥98% (HPLC), solid

Sigma-Aldrich

B7283

Benserazide hydrochloride

Benserazide hydrochloride European Pharmacopoeia (EP) Reference Standard

B0477000

Benserazide hydrochloride

Benserazide for peak identification A European Pharmacopoeia (EP) Reference Standard

Y0002115

Benserazide for peak identification A

Benserazide hydrochloride British Pharmacopoeia (BP) Reference Standard

BP685

Benserazide hydrochloride

assay

≥98% (HPLC)

assay

-

assay

-

assay

-

form

solid

form

-

form

-

form

solid

Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

-

storage temp.

room temp

storage temp.

-

storage temp.

2-8°C

storage temp.

2-8°C

solubility

H2O: 10 mg/mL

solubility

-

solubility

-

solubility

-

originator

Roche

originator

-

originator

-

originator

-

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pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCH7703
BCCF3274
BCCC7474
BCBZ1809
BCBT2136

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Restoration of the dopamine transporter through cell therapy improves dyskinesia in a rat model of Parkinson?s Disease
Tomas D, et al.
PLoS ONE, 11(4), e0153424-e0153424 (2016)
Benserazide, a dopadecarboxylase inhibitor, suppresses tumor growth by targeting hexokinase 2
Li W, et al.
Journal of Experimental & Clinical Cancer Research, 36(1), 58-58 (2017)
24 - Extrapyramidal movement disorders and spasticity
Waller DG, et al.
Medical Microbiology, 325-336 (2018)
View All Related Papers

Global Trade Item Number

SKUGTIN
B7283-5G04061833441725
B7283-1G04061833441718

Questions

  1. What is the recommended storage temperature for Benserazide hydrochloride (Product B7283) after the drug is suspended in water?

    1 answer

    1. Benserazide hydrochloride is soluble in water and should be dissolved in oxygen-free boiled water containing 0.1% sodium metabisulfite or other antioxidants. The solutions decompose on exposure to light and air. Benserazide HCl is a tan, photosensitive solid and should be stored tightly sealed at -4°C, protected from exposure to light. It is not recommended to store the aqueous solution for more than one day.

      Additionally, the product is subject to oxidation, and it is advisable to make solutions fresh daily. The product should be stored, as supplied, at room temperature for up to 1 year, and it should be protected from light.

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