D7802

Daidzein

≥98% (TLC), powder, carbonic anhydrase (CA) inhibitor

• Synonym(s): 4′,7-Dihydroxy­iso­flavone, 7-Hydroxy-3-(4-hydroxy­phenyl)-4H-1-benzo­pyran-4-one, 7-Hydroxy-3-(4-hydroxy­phenyl)­chromone, Isoaurostatin
• Empirical Formula (Hill Notation): C₁₅H₁₀O₄
• CAS Number: 486-66-8
• Molecular Weight: 254.24
• NACRES: NA.77
• PubChem Substance ID: 24278030
• UNSPSC Code: 12352202
• EC Number: 207-635-4
• MDL number: MFCD00016954
• Beilstein/REAXYS Number: 231523
• Assay: ≥98%
• Form: powder
• Quality level: 200

Properties

• Product Name: Daidzein, ≥98%, synthetic
• biological source: synthetic
• Quality Level: 200
• assay: ≥98%
• form: powder
• mp: >290 °C
• solubility: DMSO: 10 mg/mL
• storage temp.: −20°C
• SMILES string: Oc1ccc(cc1)C2=COc3cc(O)ccc3C2=O
• InChI: 1S/C15H10O4/c16-10-3-1-9(2-4-10)13-8-19-14-7-11(17)5-6-12(14)15(13)18/h1-8,16-17H
• InChI key: ZQSIJRDFPHDXIC-UHFFFAOYSA-N
• Gene Information: human ... ESR1(2099), ESR2(2100), UGT1A4(54657) ; mouse ... Aldh1a2(19378), Hexa(15211), Maoa(17161) ; rat ... Aldh1a2(116676)

Description

General description

Daidzein is an isoflavone present in soy. It regulates oxidative stress, angiogenesis, cell growth and apoptosis. Daidzein has antioxidant, antiestrogenic and antiatherogenic properties. It provides protection against osteoporosis.

Application

Daidzein has been used:

• as a control to evaluate fertility in rats
• to study its effects on ovarian cancer
• to simulate in vitro antioxidant activity

Biochem/physiol Actions

Daidzein is a phytoestrogen that is suggested to play a role in preventing hormone-induced cancers.[1] Arrests cell cycle at G₁ in Swiss 3T3 cells.[2]

Soy isoflavone daidzein protects against oxidative damage in liver cells induced by 7,12-dimethylbenz[a]anthracene (DMBA). Catalase and superoxide dismutase activity, down-regulated by DMBA, was restored by daidzein.

Packaging

Packaged under Argon.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319
• pcodes: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2
• Storage Class: 11 - Combustible Solids
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves