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N^G,N^G-Dimethylarginine dihydrochloride

Name: NG,NG-Dimethylarginine dihydrochloride
Brand: SIGMA

≥98% (TLC), powder, NOS inhibitor

Synonym(s):

asym-Dimethylarginine, ADMA

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About This Item

Empirical Formula (Hill Notation):

C₈H₁₈N₄O₂ · 2HCl

CAS Number:

220805-22-1

Molecular Weight:

275.18

UNSPSC Code:

12352209

PubChem Substance ID:

24278027

NACRES:

NA.77

MDL number:

MFCD00270857

Assay:

≥98% (TLC)

Form:

powder

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Properties

Product Name

N^G,N^G-Dimethylarginine dihydrochloride,

assay

≥98% (TLC)

Quality Segment

200

form

powder

solubility

water: 50 mg/mL, clear, colorless

storage temp.

room temp

SMILES string

Cl[H].Cl[H].CN(C)C(=N)NCCC[C@H](N)C(O)=O

InChI

1S/C8H18N4O2.2ClH/c1-12(2)8(10)11-5-3-4-6(9)7(13)14;;/h6H,3-5,9H2,1-2H3,(H2,10,11)(H,13,14);2*1H/t6-;;/m0../s1

InChI key

SYLNVYJOPZWPJI-ILKKLZGPSA-N

Gene Information

human ... NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846)

Description

General description

N^G,N^G-Dimethylarginine dihydrochloride is a methylated arginine derivative, which is produced by the liver. It is linked to liver cirrhosis, alcoholic hepatitis and acute liver failure (ALF).

Application

N^G,N^G- Dimethylarginine dihydrochloride has been used:

to study its effects on cardiovascular activities in rostral ventrolateral medulla (RVLM) in rats[1]
as a standard for measuring L-arginine and dimethylarginines
to study its effects on hepatic deterioration

Biochem/physiol Actions

Reversible inhibitor of nitric oxide synthetase in vivo and in vitro.

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This Item	M7033	D0390	724041
Sigma-Aldrich D4268 N^G,N^G-Dimethylarginine dihydrochloride	Sigma-Aldrich M7033 N^G-Methyl-L-arginine acetate salt	Sigma-Aldrich D0390 N^G,N^G′-Dimethyl-L-arginine di(p-hydroxyazobenzene-p′-sulfonate) salt	Sigma-Aldrich 724041 N^G,N^G-Dimethyl-d₆-L-arginine dihydrochloride
assay ≥98% (TLC)	assay ≥98% (TLC)	assay ≥99% (TLC)	assay 95% (CP)
form powder	form powder	form powder	form powder
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level -
storage temp. room temp	storage temp. -	storage temp. room temp	storage temp. −20°C
solubility water: 50 mg/mL, clear, colorless	solubility water: 49.00-51.00 mg/mL, clear to very slightly hazy, colorless to faintly yellow	solubility methanol: 10 mg/mL	solubility -
Gene Information human ... NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846)	Gene Information human ... NOS1(4842), NOS2(4843), NOS3(4846) mouse ... Nos2(18126) rat ... Nos1(24598), Nos2(24599)	Gene Information -	Gene Information -

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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