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A8346

Sigma-Aldrich

ProteoMass™ ACTH Fragment 18-39 MALDI-MS Standard

vial of 10 nmol, monoisotopic mol wt 2,464.1989 Da

Synonym(s):

Adrenocorticotropic hormone fragment 18-39

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About This Item

CAS Number:
53917-42-3
MDL number:
MFCD00076159
UNSPSC Code:
41116107
PubChem Substance ID:
24891334
NACRES:
NA.24

mol wt

monoisotopic mol wt 2,464.1989 Da

Quality Level

100

packaging

vial of 10 nmol

SMILES string

CC(C)CC(NC(=O)C1CCCN1C(=O)C(Cc2ccccc2)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C)NC(=O)C(CO)NC(=O)C(CCC(O)=O)NC(=O)C(CC(O)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C)NC(=O)CNC(=O)C(CC(N)=O)NC(=O)C3CCCN3C(=O)C(Cc4ccc(O)cc4)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(NC(=O)C5CCCN5C(=O)C(N)CCCNC(N)=N)C(C)C)C(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(Cc6ccccc6)C(O)=O

InChI

1S/C112H165N27O36/c1-56(2)48-72(100(163)125-70(37-41-86(148)149)97(160)133-77(111(174)175)51-63-24-14-11-15-25-63)129-103(166)79-28-20-46-138(79)109(172)75(49-62-22-12-10-13-23-62)131-93(156)61(9)121-95(158)68(35-39-84(144)145)123-92(155)60(8)122-102(165)78(55-140)134-98(161)71(38-42-87(150)151)126-101(164)74(53-88(152)153)128-96(159)69(36-40-85(146)147)124-91(154)59(7)120-83(143)54-119-94(157)73(52-82(115)142)130-104(167)80-29-21-47-139(80)110(173)76(50-64-31-33-65(141)34-32-64)132-107(170)89(57(3)4)135-99(162)67(27-16-17-43-113)127-106(169)90(58(5)6)136-105(168)81-30-19-45-137(81)108(171)66(114)26-18-44-118-112(116)117/h10-15,22-25,31-34,56-61,66-81,89-90,140-141H,16-21,26-30,35-55,113-114H2,1-9H3,(H2,115,142)(H,119,157)(H,120,143)(H,121,158)(H,122,165)(H,123,155)(H,124,154)(H,125,163)(H,126,164)(H,127,169)(H,128,159)(H,129,166)(H,130,167)(H,131,156)(H,132,170)(H,133,160)(H,134,161)(H,135,162)(H,136,168)(H,144,145)(H,146,147)(H,148,149)(H,150,151)(H,152,153)(H,174,175)(H4,116,117,118)

InChI key

ZYDMZKPAPSZILB-UHFFFAOYSA-N

Amino Acid Sequence

Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe

General description

The single peptide or protein standard is used to calibrate and test matrix assisted laser desorption ionization (MALDI) mass spectrometers. Adrenocorticotropic hormone (ACTH) is synthesized from its precursor pro-opiomelanocortin (POMC). It is released from anterior pituitary gland in response to corticotropin-releasing hormone (CRH) from hypothalamus.

Application

Peptide calibration standard for MALDI-MS instruments; 1 vial contains 10 nmols.
ProteoMass™ ACTH fragment 18-39 MALDI-MS standard has been used as a peptide calibration standard for matrix-assisted laser desorption/ionization (MALDI)-mass spectrometry (MS) instruments.

Biochem/physiol Actions

Adrenocorticotropic hormone (ACTH) stimulates the synthesis and release of glucocorticoids and androgens through cAMP-dependent by a G-protein coupled receptor in adrenal gland. Overproduction of ACTH leads to marked skin pigmentation.

Storage and Stability

Each standard is stored at room temperature and is shipped at ambient temperature. Standard stock solutions can be frozen in aliquots, but should not be subjected to more than 3 freeze-thaw cycles. Standard solutions are recommended for use for no longer than one month after reconstitution.

Legal Information

ProteoMass is a trademark of Sigma-Aldrich Co. LLC

related product

Product No.
Description
Pricing

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Endocrinology (2001)
Salivary peptidome profiling for diagnosis of severe early childhood caries.
Sun X, et al.
Journal of Translational Medicine, 14(1), 240-240 (2016)
Patient Education: A Practical Approach (2001)
D Vieau et al.
The Journal of clinical endocrinology and metabolism, 79(5), 1503-1506 (1994-11-01)
POMC processing is frequently altered in ACTH-secreting nonpituitary tumors in which intermediate lobe-like peptides such as corticotropin-like intermediate lobe peptide (CLIP) are occasionally generated. In rodent pituitaries, the exclusive presence of prohormone convertase PC2 in the melanotrophs of the intermediate
Jessica L Costa et al.
General and comparative endocrinology, 136(1), 12-16 (2004-02-26)
alpha-Melanocyte stimulating hormone (MSH) and adrenocorticotropin (ACTH)1-24, the minimal ACTH sequence required for full activity, differ only by the 10 C-terminal amino acids of ACTH1-24. Interestingly, these ten C-terminal residues have been highly conserved throughout vertebrate evolution. To understand the
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