Following reconstitution, it is recommended to aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
A4978
Alendronate sodium trihydrate
≥97% (NMR), bone resorption inhibitor, powder
Synonym(s):
4-amino-1-hydroxy-1-phosphonobutyl phosphonic acid, monosodium, MK-217
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About This Item
Empirical Formula (Hill Notation):
C4H12NaNO7P2 · 3 H2O
CAS Number:
Molecular Weight:
325.12
UNSPSC Code:
41106300
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥97% (NMR)
Form:
powder
Pricing and availability is not currently available.
Product Name
Alendronate sodium trihydrate, ≥97% (NMR), powder
Quality Segment
assay
≥97% (NMR)
form
powder
color
white
solubility
water, double-distilled: 10 mg/mL
storage temp.
−20°C
SMILES string
[Na+].[H]O[H].[H]O[H].[H]O[H].NCCCC(O)(P(O)(O)=O)P(O)([O-])=O
InChI
1S/C4H13NO7P2.Na.3H2O/c5-3-1-2-4(6,13(7,8)9)14(10,11)12;;;;/h6H,1-3,5H2,(H2,7,8,9)(H2,10,11,12);;3*1H2/q;+1;;;/p-1
InChI key
DCSBSVSZJRSITC-UHFFFAOYSA-M
Gene Information
human ... FDPS(2224)
Application
Alendronate sodium trihydrate has been used:
- for calcium phosphate nanoparticles (nCaP)/ bisphosphonate (BP) coating on titanium implants and analyze its osteogenic capacity
- in osteogenic differentiation of human bone marrow stromal cells (hBMSCs) isolated from aged osteoporosis patients- and healthy-person
- to treat osteoblast progenitor cells and osteoblasts and study their effect on osteoblast behaviors using conventional assays and simple digital image analysis[1]
Biochem/physiol Actions
Alendronate is a nitrogen-containing bisphosphonate[1] that is known to hinder the mevalonate pathway and limit osteoclastic function and activity. Alendronate sodium trihydrate is a bone resorption inhibitor, farnesyl diphosphate synthase inhibitor, and CD45 protein tyrosine phosphatase inhibitor.
Alendronate sodium trihydrate is a bone resorption inhibitor; farnesyl diphosphate synthase inhibitor (IC50 = 460 nM); CD45 protein tyrosine phosphatase inhibitor.
Preparation Note
Following reconstitution, it is recommended to aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
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This Item | |||
|---|---|---|---|
| assay ≥97% (NMR) | assay - | assay ≥97% (NMR) | assay - |
| form powder | form - | form solid | form - |
| Quality Level 100 | Quality Level - | Quality Level 100 | Quality Level - |
| storage temp. −20°C | storage temp. - | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility water, double-distilled: 10 mg/mL | solubility - | solubility H2O: >10 mg/mL | solubility - |
| color white | color - | color white | color - |
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| A4978-100MG | 04061833375297 |
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After diluting in H2O, under what conditions should the solution be stored and what is the shelf-life?
1 answer-
Helpful?
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How should I dissolve Product A4978, Alendronate sodium trihydrate?
1 answer-
This product is soluble in water at a concentration of 10 mg/mL.
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I see that Product A4978, Alendronate sodium trihydrate, is a trihydrate. How was the water content determined?
1 answer-
Our supplier typically determines the water content by a loss on drying. We have not tested the water content in our labs here at Sigma by that method; we typically confirm the supplier’s value by CHN (elemental analysis for carbon, hydrogen and nitrogen, comparing the measured values to the theoretical values for the trihydrate).
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What quality control assays are typically done on Product A4978, Alendronate sodium trihydrate?
1 answer-
The assays typically done on Product No. A4978 are appearance, solubility, elemental analysis for carbon, hydrogen and nitrogen (CHN) and proton NMR (1H-NMR) spectroscopy. The results of these assays may be found on the certificate of analysis for each lot.
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