1430203

Methyl isobutyl ketone

United States Pharmacopeia (USP) Reference Standard

• Synonym(s): 4-Methyl-2-pentanone, Isobutyl methyl ketone, Isopropylacetone, MIBK, Methyl isobutyl ketone
• Linear Formula: (CH₃)₂CHCH₂COCH₃
• CAS Number: 108-10-1
• Molecular Weight: 100.16
• UNSPSC Code: 41116107
• NACRES: NA.24
• PubChem Substance ID: 329750440
• MDL number: MFCD00008938
• Beilstein/REAXYS Number: 605399

Properties

• grade: pharmaceutical primary standard
• vapor density: 3.5 (vs air)
• form: liquid
• autoignition temp.: 840 °F
• expl. lim.: 1.2-8 %, 93 °F
• manufacturer/tradename: USP
• refractive index: n20/D 1.395 (lit.)
• bp: 117-118 °C
• mp: −80 °C (lit.)
• density: 0.801 g/mL at 25 °C (lit.)
• application(s): USP Biologics; pharmaceutical (small molecule)
• format: neat
• SMILES string: CC(C)CC(C)=O
• InChI: 1S/C6H12O/c1-5(2)4-6(3)7/h5H,4H2,1-3H3
• InChI key: NTIZESTWPVYFNL-UHFFFAOYSA-N

Description

General description

Methyl isobutyl ketone is a versatile solvent used in various pharmaceutical and biologic formulations. It aids in the dissolution of lipophilic compounds and is employed during the extraction and purification processes. MIBK′s low volatility and solvent properties make it ideal for use in biologic formulations where stability and consistency are key.

The United States Pharmacopeia (USP) provides quality standards for biologics to ensure their safety, efficacy, and quality throughout the manufacturing process. These standards assist manufacturers in adhering to regulatory requirements and help safeguard public health by reducing risks associated with biologics.

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Methyl isobutyl ketone USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

This product is part of USP Biologics Program.

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pha

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Safety Information

• pictograms: GHS02,GHS08,GHS07
• signalword: Danger
• hcodes: H225,H319,H332,H336,H351
• pcodes: P202 - P210 - P233 - P304 + P340 + P312 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Inhalation - Carc. 2 Inhalation - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
• target_organs: Central nervous system
• supp_hazards: EUH066
• Storage Class: 3 - Flammable liquids
• wgk: WGK 1
• flash_point_f: 57.2 °F - closed cup
• flash_point_c: 14 °C - closed cup