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Carvedilol

Name: Carvedilol
Brand: USP

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol, BM-14190

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About This Item

Empirical Formula (Hill Notation):

C₂₄H₂₆N₂O₄

CAS Number:

72956-09-3

Molecular Weight:

406.47

NACRES:

NA.24

PubChem Substance ID:

329749239

UNSPSC Code:

41116107

MDL number:

MFCD00864692

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Properties

grade

pharmaceutical primary standard

API family

carvedilol

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

OC(COC1=CC=CC2=C1C3=C(C=CC=C3)N2)CNCCOC4=CC=CC=C4OC

InChI

1S/C24H26N2O4/c1-28-21-10-4-5-11-22(21)29-14-13-25-15-17(27)16-30-23-12-6-9-20-24(23)18-7-2-3-8-19(18)26-20/h2-12,17,25-27H,13-16H2,1H3

InChI key

OGHNVEJMJSYVRP-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRB1(153), ADRB2(154), ADRB3(155)

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Carvedilol USP Reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monograph such as Carvedilol Tablets

Biochem/physiol Actions

Cavedilol is a non-selective β-adrenergic blocker with α1 blocking activity.

Cavedilol is a non-selective β-adrenergic blocker with α1 blocking activity. Carvedilol is used specifically for the treatment of heart failure and high blood pressure. It has been shown to improve left ventricular ejection fraction and may reduce mortality.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

Other Notes

Sales restrictions may apply.

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This Item	Y0001427	PHR1265	Y0001426
USP 1096622 Carvedilol	Y0001427 Carvedilol	Supelco PHR1265 Carvedilol	Y0001426 Carvedilol for system suitability
grade pharmaceutical primary standard	grade pharmaceutical primary standard	grade certified reference material, pharmaceutical secondary standard	grade pharmaceutical primary standard
manufacturer/tradename USP	manufacturer/tradename EDQM	manufacturer/tradename -	manufacturer/tradename EDQM
application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)
format neat	format neat	format neat	format neat
API family carvedilol	API family carvedilol	API family carvedilol	API family carvedilol
Gene Information human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRB1(153), ADRB2(154), ADRB3(155)	Gene Information human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRB1(153), ADRB2(154), ADRB3(155)	Gene Information human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRB1(153), ADRB2(154), ADRB3(155)	Gene Information human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRB1(153), ADRB2(154), ADRB3(155)

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pictograms

GHS08,GHS09

signalword

Warning

hcodes

H373,H411

pcodes

P260 - P273 - P314 - P391 - P501

Hazard Classifications

Aquatic Chronic 2 - STOT RE 2

target_organs

Liver,spleen,Uterus (including cervix),Adrenal gland

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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Impact of carvedilol on the serum lipid profile.

Randall P Sharp et al.

The Annals of pharmacotherapy, 42(4), 564-571 (2008-03-28)

To examine the evidence regarding the impact of carvedilol on the serum lipid profile. Searches in MEDLINE and International Pharmaceutical Abstracts (1966-December 2007) were conducted. Search terms included carvedilol, cholesterol, lipids, hyperlipidemia, and beta-blockers. Published studies and case reports that

The role of carvedilol in the management of portal hypertension.

Dhiraj Tripathi et al.

European journal of gastroenterology & hepatology, 22(8), 905-911 (2010-01-23)

Carvedilol is a potent noncardioselective beta-blocker, with weak vasodilating properties because of alpha 1 blockade. A reduction in both intrahepatic and portocollateral resistance contribute to enhanced effects on portal pressure. There are 10 published hemodynamic studies involving 168 patients investigating

Meta-analysis comparing carvedilol versus metoprolol for the prevention of postoperative atrial fibrillation following coronary artery bypass grafting.

James J DiNicolantonio et al.

The American journal of cardiology, 113(3), 565-569 (2013-12-18)

A systematic review and meta-analysis was performed to evaluate the effects of carvedilol versus metoprolol on the incidence of postoperative atrial fibrillation in patients undergoing coronary artery bypass grafting in randomized controlled trials. Ovid MEDLINE, PubMed, CENTRAL, and Excepta Medica

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Global Trade Item Number

SKU	GTIN
1096622-200MG	04061838688866

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