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T4264

Tetrahydrozoline hydrochloride

≥98% (HPLC)

Synonym(s):

4,5-Dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-1H-imidazole monohydrochloride, Tetryzoline hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C13H16N2 · HCl
CAS Number:
522-48-5
Molecular Weight:
236.74
NACRES:
NA.77
PubChem Substance ID:
24278736
UNSPSC Code:
12352200
EC Number:
208-329-3
MDL number:
MFCD00058029
Assay:
≥98% (HPLC)
Quality level:
200
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Quality Level

200

assay

≥98% (HPLC)

solubility

H2O: freely soluble, alcohol: freely soluble, chloroform: very slightly soluble, diethyl ether: insoluble

originator

Novartis

SMILES string

Cl.C1CC(C2=NCCN2)c3ccccc3C1

InChI

1S/C13H16N2.ClH/c1-2-6-11-10(4-1)5-3-7-12(11)13-14-8-9-15-13;/h1-2,4,6,12H,3,5,7-9H2,(H,14,15);1H

InChI key

BJORNXNYWNIWEY-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)

Biochem/physiol Actions

Tetrahydrozoline is an α-adrenergic agonist and an imidazoline derivative.[1][2] It plays a crucial role in the constriction of conjunctival blood vessels.[2] Tetrahydrozoline is a common component of nasal and eye drop formulations.[2]

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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This Item
1652001Y0000460T6950
Tetrahydrozoline hydrochloride ≥98% (HPLC)

Sigma-Aldrich

T4264

Tetrahydrozoline hydrochloride

Tetrahydrozoline hydrochloride United States Pharmacopeia (USP) Reference Standard

USP

1652001

Tetrahydrozoline hydrochloride

Tetrahydrozoline hydrochloride European Pharmacopoeia (EP) Reference Standard

Y0000460

Tetrahydrozoline hydrochloride

Tizanidine hydrochloride ≥98% (HPLC), powder

Sigma-Aldrich

T6950

Tizanidine hydrochloride

assay

≥98% (HPLC)

assay

-

assay

-

assay

≥98% (HPLC)

Quality Level

200

Quality Level

-

Quality Level

-

Quality Level

100

solubility

H2O: freely soluble, chloroform: very slightly soluble, alcohol: freely soluble, diethyl ether: insoluble

solubility

-

solubility

-

solubility

H2O: >20 mg/mL

originator

Novartis

originator

-

originator

-

originator

Acorda Therapeutics

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)

Gene Information

human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)

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pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000493073
0000493073
0000436956
0000436956
SLCB7381

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P J Rice et al.
The Journal of pharmacology and experimental therapeutics, 259(3), 1182-1187 (1991-12-01)
Repeated exposure of the rat vas deferens to the imidazoline oxymetazoline (OXY) results in a progressive loss of response which can appear selective for imidazoline agonists. The present study tests the hypothesis that imidazolines produce desensitization through prolonged blockade or
Gary N W Leung et al.
Journal of chromatography. A, 1156(1-2), 271-279 (2006-10-24)
This paper describes a high throughput LC-MS-MS method for the screening of 75 basic drugs in equine plasma at sub-ppb levels. The test scope covers diversified classes of drugs including some alpha- and beta-blockers, alpha- and beta-agonists, antihypotensives, antihypertensives, analgesics
Henry Spiller et al.
Clinical toxicology (Philadelphia, Pa.), 46(2), 171-172 (2008-02-09)
Tetrahydrozoline is an imidazoline derivative with alpha receptor agonist activity widely available in over-the-counter topical ocular and nasal formulations. More than 1,600 cases of oral exposures are reported to United States poison centers annually (1,2). Reports of significant toxicity from
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Global Trade Item Number

SKUGTIN
T4264-1G04061825983776
T4264-10G04061832094021

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