S4568

SCH 58261

≥98% (HPLC), adenosine receptor antagonist, solid

• Synonym(s): 7-(2-phenylethyl)-5-amino-2-(2-furyl)-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine
• Empirical Formula (Hill Notation): C₁₈H₁₅N₇O
• CAS Number: 160098-96-4
• Molecular Weight: 345.36
• UNSPSC Code: 12352200
• PubChem Substance ID: 329824547
• NACRES: NA.77
• MDL number: MFCD00933778
• Assay: ≥98% (HPLC)
• Form: solid

Properties

• Product Name: SCH 58261, ≥98% (HPLC), solid
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• color: off-white
• solubility: DMSO: soluble >10 mg/mL, H₂O: insoluble
• SMILES string: Nc1nc2n(CCc3ccccc3)ncc2c4nc(nn14)-c5ccco5
• InChI: 1S/C18H15N7O/c19-18-22-16-13(11-20-24(16)9-8-12-5-2-1-3-6-12)17-21-15(23-25(17)18)14-7-4-10-26-14/h1-7,10-11H,8-9H2,(H2,19,22)
• InChI key: UTLPKQYUXOEJIL-UHFFFAOYSA-N

Description

Application

SCH 58261 was used to block A2α adenosine receptor to study the signaling by prostatic acid phosphatase in neurons.⁴

Biochem/physiol Actions

A_2A adenosine receptor antagonist.

SCH 58261 reduces the levels of TNF-α, Fas-L, Bax expression and activation of JNK-MAPK pathway. It has neuroprotective effects as it reduces demyelination of the neurons. SCH 58261 increases the concentration of secretion of dopamine and elicits locomotor sensitization, an attractive option in the possible treatment of Parkinson′s disease.

Features and Benefits

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)